Results 141 to 150 of about 1,983,299 (303)

The best exercises from top 20 by health-related indicators

Frontiers in Public Health
BackgroundThe study aimed to determine whether participation in professional sports, exercise in a sports/health center, or independent exercise (dependent variables) is associated with 11 health behavior-related indicators (independent variables ...
Albertas Skurvydas, Natalja Istomina, Dovilė Valanciene, Ruta Dadeliene, Ieva Egle Jamontaite, Ausra Lisinskiene, Asta Sarkauskiene, Daiva Majauskiene, Daiva Majauskiene   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Role of Limited Emotion Regulation Strategies on Nonsuicidal Self-injury and Suicide Attempts among Chinese Adolescents: A Network Analysis Based on Jiangxi Province

Health Data Science
Background: Nonsuicidal self-injuries (NSSIs) are an important contributing factor to adolescent suicide, and various shared factors influence the risk of both NSSIs and suicide attempts (SAs).
Hao Xu, Xuejing Xu, Yan Chen, Wei Qu, Yunlong Tan, Zhiren Wang, Yanli Zhao, Shuping Tan, Dianying Liu   +8 more
doaj   +1 more source

Changes in Body Mass Index Associated With Head Start Participation

Pediatrics, 2015
J. Lumeng, N. Kaciroti, J. Sturza, Allison M. Krusky, Alison L. Miller, K. Peterson, R. Lipton, T. Reischl   +7 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A review of the status of e-government implementation in Kenya

Regional Journal of Information and Knowledge Management, 2017
Rationale of Study – Successful implementation of today’s government operations requires effective policy making and system monitoring through relevant data and information.
Esther Nderitu Imbamba, Nancy Kimile
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source