Results 151 to 160 of about 882,596 (264)

Index Numbers [PDF]

Index numbers are used to aggregate detailed information on prices and quantities into scalar measures of price and quantity levels or their growth. The paper reviews four main approaches to bilateral index number theory where two price and quantity ...
Diewert, Erwin
core  

Organized community sport participation for children and youth with physical disability: A scoping review protocol. [PDF]

PLoS One
Davies K, Barran M, Pawliuk C, Choi T, Schilbach Pizzutto B, Lai K, Moreno Grangeiro P, Pollock CL.   +7 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Editorial: Multidimensional benefits of the Mediterranean diet across the lifespan and cultures. [PDF]

Front Nutr
Pederiva C, Banderali G.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Participation in higher education: A geodemographic perspective on the potential for further expansion in student numbers [PDF]

Higher Education in England has expanded dramatically in the last ten years with the result that currently more than 30 per cent of young people go on to University. This upward trend in the participation rate is almost certain to continue, following the
Peter Brown, Peter Batey
core  

The role of personal and psychological, social and environmental factors in determining physical activity in Turkish school-aged adolescents: in the context of a socio-ecological model. [PDF]

Front Psychol
Çifçi F, Demir A.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cross-country variability in Mediterranean lifestyle adherence and its psychosocial and behavioural correlates: insights from the MEDIET4ALL project across 10 Mediterranean and neighboring countries. [PDF]

Front Nutr
Ammar A, Salem A, Zarzissi S, Abril-Mera T, Trabelsi K, Bouaziz B, Boujelbane MA, Kerkeni M, Masmoudi L, Heydenreich J, Schallhorn C, Müller G, Uyar AM, Ghazzawi HA, Amawi AT, Orhan BE, Grosso G, Abdelkarim O, Driss T, El Abed K, Moalla W, Zmijewski P, Debeaufort F, Benbettaieb N, Poulain C, Reyes L, Gamero A, Cuenca-Ortolá M, Cilla A, Francesca N, Messina CM, Viola E, Lorenzen B, Filice S, Lahiani S, Khaldi T, Souissi N, Boukhris O, Frias-Toral E, Jahrami H, Husain W, Mahdi W, Souissi N, Chtourou H, Schöllhorn WI.   +44 more
europepmc   +1 more source