Results 151 to 160 of about 33,283,713 (295)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

HistoBreastCAD: an integrated deep learning framework for segmentation and multiclass classification of whole-slide breast histopathology images. [PDF]

Front Bioinform
Celi-Vega O, Jiménez-Gaona Y, Corral-Dominguez P, Gutiérrez Á, Socola-Barzallo Z.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Fluent but not fail-safe: machine-translated radiology reports still need expert review. [PDF]

Eur Radiol Exp
Seibold C, Leichenich T, Stein P, Atsiatorme E, Kliesch P, Sevim GA, Trauth P, Kremer A, Bischoff A, Kauczor HU, Fink MA.   +10 more
europepmc   +1 more source

E-Reader Instructions

Tradition and Discovery: The Polanyi Society Periodical, 2015
openaire   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

OpenMSK: A modular open-source framework for comprehensive analysis of imaging biomarkers in knee osteoarthritis. [PDF]

Osteoarthr Cartil Open
Goyal A, Belibi F, Sahani V, Pedersen R, Vainberg Y, Williams A, Chu C, Haddock B, Gold GE, Chaudhari AS, Kogan F, Gatti AA.   +11 more
europepmc   +1 more source

I riti della sociabilità inglese e la costruzione del 'common reader'

, 2016
L’intervento riflette attorno al complesso rapporto, nella Gran Bretagna del XVIII secolo, tra luoghi di riunione, di scambio e di lettura, e un modo nuovo di leggere e di partecipare al dibattito politico-culturale .
DE ROMANIS, Roberto
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

eeeHive: a new HF RFID-based automated behavioral monitoring system enabling high spatiotemporal resolution tracking of group-housed animals. [PDF]

Front Behav Neurosci
Benner S, Shiono S, Kagawa T, Hattori K, Yamasue H, Lipp HP, Endo T.   +6 more
europepmc   +1 more source