Results 61 to 70 of about 120,893 (190)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Frontiers in Public HealthBackgroundThe rapid evolution of Influenza A(H3N2) requires constant global monitoring. This study analyzes the genomic characteristics and the first introduction of the emerging subclade K (J.2.4.1) in Ecuador, utilizing publicly available data to trace
Alfredo Bruno +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
El marco de desarrollo de la e-Salud en España
, 2001 Producido por Area de Investigacion en Telemedicina y Sociedad de la Informacion, Instituto de Salud Carlos ...
openaire +3 more sources
Microcefalia en Argentina según datos de la Red Nacional de Anomalías Congénitas [PDF]
Revista Argentina de Salud Pública, 2016 En Brasil se ha notificado un aumento en la prevalencia de microcefalia en recién nacidos, que coincide con la epidemia del virus del Zika. El objetivo de este estudio fue describir la frecuencia de microcefalia en Argentina y estimar el número de casos ...
Boris, Groisman +3 more
doaj
Diagnostic Tools for the Identification of Babesia sp. in Persistently Infected Cattle
Pathogens, 2019 Bovine babesiosis is a tick-borne disease of cattle caused by the protozoan parasites of the genus Babesia. Babesia bovis, Babesia bigemina and Babesia divergens are considered by International health authorities (OIE) as the principal species of Babesia
J. Antonio Alvarez +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Perioperative allergy. A 3-year experience
Revista Alergia México, 2018 Background: Perioperative hypersensitivity reactions constitute a global health problem, with an estimated incidence of 1 per 100,000 procedures and a mortality rate of 0.1 to 9 %.
Rodrigo Collado-Chagoya +6 more
doaj +1 more source