Results 71 to 80 of about 120,893 (190)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prevalencia de anomalías congénitas en Argentina y su potencial impacto en los servicios de salud [PDF]

Revista Argentina de Salud Pública, 2014
El mayor control de las infecciones y la desnutrición en Argentina dio lugar a un incremento relativo de las anomalías congénitas (AC), que son actualmente una de las causas principales de mortalidad infantil.
María Paz. Bidondo , Boris, Groisman , Juan ,Gili , Rosa, Liascovich, Pablo , Barbero   +4 more
doaj  

Preparación para la maternidad y paternidad: experiencia exitosa con e-salud

MedUNAB
Las tecnologías de la información y la comunicación (TIC) han cambiado la concepción del mundo, y por tanto de la salud. La Organización Mundial de la Salud define el manejo de las TIC como “el uso coste-efectivo y seguro de las tecnologías de la información y comunicación en apoyo a salud y a los ámbitos relacionados con la salud, incluyendo los ...
Diana María Reyes-Bravo, Mary Luz Jaimes-Valencia, Socorro Fajardo-Natez, Diana Mercedes Angarita-Macias   +3 more
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Strategy for the Generation of Engineered Bone Constructs Based on Umbilical Cord Mesenchymal Stromal Cells Expanded with Human Platelet Lysate

Stem Cells International, 2019
Umbilical cord mesenchymal stromal cells (UC-MSC) are promising candidates for cell therapy due to their potent multilineage differentiation, enhanced self-renewal capacity, and immediate availability for clinical use.
Ingrid Silva-Cote, Mónica Cruz-Barrera, Mariana Cañas-Arboleda, Luz Correa-Araujo, Leidi Méndez, Joanna Jagielska, Bernardo Camacho, Gustavo Salguero   +7 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Factors associated with the severity and complication of patients with malaria hospitalized between 2009 and 2013 in three municipalities of Colombia, case control study

Malaria Journal, 2016
Background Malaria worldwide annual reported cases range between 250 and 500 million and nearly half a million deaths are reported every year. Colombia has a vast expanse of territory with environmental and social conditions conducive to malaria ...
Jesica F. Ramírez, Beatriz Porras, Elizabeth Borrero, Sandra P. Martínez   +3 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Leptospirosis humana en Argentina: un esquema de análisis, 2014 [PDF]

Revista Argentina de Salud Pública, 2020
En general, sólo existen estimaciones sobre el número de casos de leptospirosis en las Américas. La fuente más común son los Ministerios de Salud, tanto nacionales como provinciales, que proporcionan datos útiles sobre tendencias de incidencia de la ...
Paulina, Jacob , Yosena, Chiani , Ma. Fernanda , Schmeling, Noelia, Landolt , Nazarena , Pujato , Bibiana, Vanasco   +5 more
doaj  

Modelado experimental de un sistema de e-salud aplicado en cooperación al desarrollo

, 2022
Los Objetivos de Desarrollo del Milenio comprometieron a los países con una nueva alianza mundial de alcanzar gradualmente una cobertura universal de los niveles mínimos de bienestar en los países en desarrollo (reducir la pobreza y el hambre y dar respuesta a problemas como la mala salud, las desigualdades de género, la falta de educación, el acceso a
openaire   +2 more sources