Results 121 to 130 of about 21,662,479 (296)

Intercellular adhesion molecules as novel markers of endothelial function in patients with diabetes mellitus in the South Indian population

Journal of Clinical and Scientific Research
Background: Circulating levels of, cell adhesion molecules (CAMs) are considered to be surrogate markers of endothelial function. Our study aimed to evaluate the circulating levels of CAMs, namely, intercellular adhesion molecule 1 (ICAM-1) and ...
J. Ashwini Kumari, M. Vijaya Bhaskar, Arshi Sanober, Iyyapu Krishna Mohan, N. N. Sreedevi, Mohammed Noorjahan, Kompella S S Saibaba, Siraj Ahmed Khan   +7 more
doaj   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

E-selectin modulates the malignant properties of T84 colon carcinoma cells

, 2002
The extravasation of metastatic cells is regulated by molecular events involving the initial adhesion of tumor cells to the endothelium and subsequently the migration of cells in the host connective tissue.
D'Amato, M, De Leo, G, Alaimo, G, Di Bella, M A, Russo, D, Flugy, A M, Kohn, E C, Alessandro, R   +7 more
core   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Kinetic measurements of E-selectin/carbohydrate ligand interactions on the cell surface

, 2001
The kinetic measurements of E-selectin/carbohydrate ligand interactions were performed on the cell surface. The micropipette method was applied to the study of E-selectin/carbohydrate ligand interactions and extended from adhesion kinetic measurements to
龙勉, Huang KS, Zhao H
core  

Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins, Sandhi M. Barreto, Lidyane V. Camelo, Sara T. Menezes, Naomi M. Hamburg, Maria de Fatima H. S. Diniz, Antonio L. P. Ribeiro, Luisa C. C. Brant   +7 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Value of adhesion molecules for evaluating the efficiency of therapy for ulcerative colitis and Crohn's disease

Терапевтический архив, 2014
AIM: To define the value of adhesion molecules (sVCAM-1 integrin, P-selectin, E-selectin, and L-selectin) for the prediction and evaluation of the efficiency of treatment in patients with ulcerative colitis (UC) and Crohn's disease/MATERIAL AND METHODS ...
A I Parfenov, O N Boldyreva, I N Ruchkina, O V Kniazev, V É Sagynbaeva, P L Shcherbakov, S G Khomeriki, L B Lazebnik, A G Konopliannikov   +8 more
doaj