Results 111 to 120 of about 50,139,323 (325)

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells

, 2005
Objective. The two endothelial selectins, P- and E-selectin, are critically important for adhesion and homing of hematopoietic progenitor cells (HPC) into the bone marrow. Little is known, however, about the roles of these two selectins in hematopoiesis.
Levesque, Jean-Pierre, Purton, Louise E., Winkler, Ingrid, Eto, Tetsuya   +3 more
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Silencing α1,3-Fucosyltransferases in Human Leukocytes Reveals a Role for FUT9 Enzyme during E-selectin-mediated Cell Adhesion*

Journal of Biological Chemistry, 2012
Background: During inflammation, the selectins engage glycosylated macromolecules expressed on blood leukocytes under fluid shear conditions. Results: Although all three myeloid α1,3-fucosyltransferases FUT9, FUT7, and FUT4 regulate human E-selectin ...
Alexander Buffone, Nandini Mondal, Rohitesh Gupta, Kyle McHugh, Joseph T. Y. Lau, S. Neelamegham   +5 more
semanticscholar   +1 more source

Functions of E-selectin.

Trends in Glycoscience and Glycotechnology, 1994
細胞接着分子であるセレクチンファミリーのE-、P-、L-セレクチンは、共通のドメイン構造を持ち、似たような糖鎖認識を行うので一つのファミリーとなっている。セレクチンはインテグリンや免疫グロブリン様の細胞接着分子と一緒になって、白血球の血管内皮細胞への接着に関与している。これらの接着分子の一過性発現と細胞に特異的な結合特性が白血球を召集して戦地である炎症部位に赴かせるのに役立っている。本論文は、E-セレクチンの構造、糖鎖結合性、および機能についての最近の論文の総説である。
openaire   +2 more sources

Serum E-selectin specific antibodies.

, 2013
Serum was collected after 7 weeks on a high-fat diet. (A) Human E-selectin specific IgG1, IgG2a and total IgG in mice on regimen A (N = 5 per group) or regimen B (N = 24 for PBS group, N = 23 for E-selectin group).
Xinhui Li (349485), Mark Bryant (349488), Jacqueline A. Quandt (349492), Abdel G. Elkahloun (208396), John M. Hallenbeck (125851), Ranil De Silva (349491), Marcelo Amar (349490), Kory R. Johnson (125846), Alan T. Remaley (77852)   +8 more
core   +1 more source

Hyperbranched poly‐L‐lysine surface‐engineered bioprosthetic heart valves with anti‐calcification, anti‐infection, and durability

BMEMat, EarlyView.
The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng, Dongchao Qiu, Yongyuan Kang, Qiaoxuan Wang, Xuelong Wang, Boyana Parvanova, Miroslav Karabaliev, Changyou Gao   +7 more
wiley   +1 more source

DataSheet_1_Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis.docx

, 2022
Nanodiamond (ND) has been developed as a carrier to conduct various in vivo diagnostic and therapeutic uses. Safety is one of the major considerations, while the hemocompatibility of ND is not clearly addressed.
Lu-Chu Ke (12339820), Hsin-Hou Chang (221399), Te-Sheng Lien (359060), Hsuan-Shun Huang (359058), Chia-Liang Cheng (2476663), Shih-Che Hung (10314449), Der-Shan Sun (331824)   +6 more
core   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E- selectin expression in human squamous cell carcinomas

Journal of Investigative Dermatology, 2012
Squamous cell carcinomas (SCC) are sun-induced skin cancers that are particularly numerous and aggressive in immunosuppressed individuals. SCC evade immune detection at least in part by down-regulating E-selectin on tumor vessels, thereby restricting ...
A. Gehad, Michael K. Lichtman, C. Schmults, J. Teague, Adam Calarese, Ying Jiang, R. Watanabe, R. Clark   +7 more
semanticscholar   +1 more source