Results 91 to 100 of about 21,662,479 (296)

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Additional file 4: of Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression

, 2018
Figure S2. Binding of sulfatide-expressing MDA.SUL cells to (A) P-selectin-expressing CHO-Pro-5 (CHO-Pro/SELP) cells or (B) E-selectin-expressing CHO-Pro-5 (CHO-Pro/SELE) cells under flow conditions.
Maciej Ugorski (159528), Tomasz Owczarek (733501), Bartlomiej Kocbach (5939963), Pawel Pasikowski (5939960), Jedrzej Grzegrzolka (4455229), Aleksandra Piotrowska (4455226), Aleksandra Nowak (5939966), Andrzej Wojnar (11191), Piotr Dziegiel (504310), Jaroslaw Suchanski (733498)   +9 more
core   +1 more source

P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand. [PDF]

, 2009
Cell adhesion molecules are critical to wound healing through leukocyte recruitment. Although P-selectin glycoprotein ligand-1 (PSGL-1) regulates leukocyte rolling by binding P-selectin, but also binding E- and L-selectins with lower affinity, little is ...
Ayumi Yoshizaki, Iwata, Yohei, Kazuhiro Komura, Manabu Fujimoto, Hasegawa, Minoru, Sato, Shinichi, Toshihide Hara, Koichi Yanaba, Fujimoto, Manabu, Tomita, Hajime, Motoi Takenaka, Komura, Kazuhiro, Yanaba, Koichi, Minoru Hasegawa, Muroi, Eiji, Hara, Toshihide, Bae, Sangjae, Takenaka, Motoi, Fumihide Ogawa, Shimizu, Kazuhiro, Ogawa, Fumihide, Yoshizaki, Ayumi, Eiji Muroi, Kazuhiro Shimizu, Shinichi Sato, Yohei Iwata, Hajime Tomita, Sangjae Bae   +27 more
core   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice

, 2007
In multiple sclerosis and in its animal model experimental autoimmune encephalomyelitis (EAE), inflammatory cells migrate across the endothelial blood-brain barrier (BBB) and gain access to the CNS.
Engelhardt, B., Martin Wild, Engelhardt, Britta, Wild, Martin, Deutsch, Urban, Wild, M., Dietmar Vestweber, Doring, A., Britta Engelhardt, Döring, Axinia, Axinia Döring, Vestweber, Dietmar, Vestweber, D., Deutsch, U., Urban Deutsch   +14 more
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

The Ser128Arg polymorphism for E-selectin gene and brucellosis

Infection, Genetics and Evolution, 2007
E-selectin is expressed on activated endothelial cells and plays an important role in regulating the early steps of tethering and rolling of leukocytes into and within sites of infection and inflammation. An A/C polymorphism (Ser128Arg) has been descried to alter ligand binding function. Therefore, the purpose of this case-control association study was
Alireza, Rafiei, Mehrdad, Hajilooi, Mohammad, Vahedi, Reza Jafari, Shakib   +3 more
openaire   +2 more sources