Results 121 to 130 of about 1,341,006 (309)

Initiation and Up-titration of Guideline-directed Medical Therapy for Patients with Heart Failure: Better, Faster, Stronger!

Cardiac Failure Review
Treatment for heart failure has experienced a major revolution in recent years, and current evidence shows that a combination of four medications (angiotensin receptor-neprilysin inhibitors + β-blockers + mineralocorticoid receptor antagonists + sodium ...
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, José Arturo Vargas-Mendoza, Raymundo Vera-Pineda, Ramiro Flores-Ramírez   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Paediatric dental A&E service during the COVID-19 pandemic in the Greater London area. [PDF]

Eur Arch Paediatr Dent, 2021
Patel N, Viswanathan A, Lee J, Barrow S, Cant A, Sanghvi R, Deseta M, Layton J, Bhujel N, Sheehy EC.   +9 more
europepmc   +1 more source

PENGARUH E-SERVICE QUALITY TERHADAP CORPORATE IMAGE PERUSAHAAN PENERBANGAN PT. SRIWIJAYA AIR : Survey pada On Sales PT.Sriwijaya Air [PDF]

, 2015
PT. Sriwijaya Air merupakan salah satu maskapai penerbangan di Indonesia yang berorientasi pada penerbangan domestik. Mengingat profil perusahaan yang cukup dikenal pada bidang transportasi udara oleh masyarakat Indonesia karena harga dan kualitas yang ...
Magdalena, Maria
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pseudonym Technology for E-Services

, 2011
Pseudonym technology is attracting more and more attention and, together with privacy violations, is becoming a major issue in various e-services. Current e-service systems make personal data collection very easy and efficient through integration, interconnection, and data mining technologies since they use the user’s real identity.
Song, Ronggong, Korba, Larry, Yee, George   +2 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A conceptual model of enterprise application integration in higher education institutions [PDF]

, 2013
Copyright @ 2013 EMCIS.It is eminent that several applications’ systems are deployed at different levels in Higher Education (HE), ranging from academic and administrative to staff and students record systems.
Alshawi, SN, Aserey, N
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source