Results 71 to 80 of about 309,262 (293)

Phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury

open access: yes, 2011
Recent work has demonstrated that the formation of platelet neutrophil complexes (PNCs) affects inflammatory tissue injury. Vasodilator-stimulated phosphoprotein (VASP) is crucially involved into the control of PNC formation and myocardial reperfusion ...
Birk, Philipp   +13 more
core   +1 more source

Homology Modelling of Human E1 Ubiquitin Activating Enzyme [PDF]

open access: yes, 2010
Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M.
Brahemi, Ghali   +3 more
core   +1 more source

The molecular architecture of E1.

open access: yes, 2023
(A) Ribbon diagrams of predicted E1 structures for HCV, HCV-P, SPgV, and BVDV; features are colour coded as shown on the HCV structure, left. The approximate location of the outer leaflet of the viral membrane is inferred by the positions of the E1 ...
Robert J. Gifford (12488303)   +5 more
core   +1 more source

In Situ Crystalline‐Amorphous Composite Oxide Structure Suppressing Thermal Wear Instability for Refractory Multi‐Principal Element Alloy

open access: yesAdvanced Functional Materials, EarlyView.
An effective strategy is developed to overcome the medium temperatures wear resistance degradation in refractory multi‐principal element alloys. By utilizing chemical short‐range ordering to trigger oxygen‐induced amorphization, a composite oxide structure is formed, which combines high hardness with robust stiffness.
Xuhui Pei   +7 more
wiley   +1 more source

Engineering Pendant Group Chemistry to Control Hydrophilicity and Oxidative Degradation of Thioketal‐Based Biomaterials

open access: yesAdvanced Functional Materials, EarlyView.
Thioketal (TK) polymers are promising biomaterials due to their selective biodegradation by reactive oxygen species (ROS), but they respond slowly to physiologic doses of ROS. Here, the TK bond's pendant groups are modified to enhance the degradation of TK‐based implants both in vitro and in vivo.
Karina A. Bruce   +6 more
wiley   +1 more source

Dynamic calibration method of capacitive pressure measuring device

open access: yesJournal of Measurement Science and Instrumentation, 2013
This paper presents working principle,structure and a dynamic calibration method of capacitive pressure measuring device.Using this method,placing calibrated capacitive electronic pressure measuring device and three standard sensors in simulation chamber
FAN Jun-xia1, LI Xin-e1
doaj  

Novel KCNQ1 Q234K variant, identified in patients with long QT syndrome and epileptiform activity, induces both gain- and loss-of-function of slowly activating delayed rectifier potassium currents

open access: yesFrontiers in Physiology
IntroductionKCNQ1 and KCNE1 form slowly activating delayed rectifier potassium currents (IKs). Loss-of-function of IKs by KCNQ1 variants causes type-1 long QT syndrome (LQTS). Also, some KCNQ1 variants are reported to cause epilepsy.
Tadashi Nakajima   +14 more
doaj   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

open access: yesAdvanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira   +3 more
wiley   +1 more source

Cell-based analysis of Chikungunya virus E1 protein in membrane fusion

open access: yesJournal of Biomedical Science, 2012
Background Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm ...
Kuo Szu-Cheng   +6 more
doaj   +1 more source

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

open access: yesAdvanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee   +10 more
wiley   +1 more source

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