Frontiers in Immunology, 2018 Estradiol (E2) plays a crucial and intricate role during pregnancy to mediate several aspects of the pregnancy process. A perplexing phenomenon in congenital toxoplasmosis is that the severity of Toxoplasma gondii (T.
Jingfan Qiu +11 more
doaj +1 more source
E2-T179N increases viral replication of MAYV and CHIKV in insect cells and causes early release.
, 2023 A-C: Replication of WT MAYV and MAYV E2-T179N in insect and human cells. Aag2 (A) and U4.4 (B) cells were infected with WT MAYV or MAYV E2-T179N at a MOI of 0.1, while MRC-5 were infected at a MOI of 0.01 (C). Replication was assessed over time by plaque
Rafael Elias Marques (9953951) +22 more
core +1 more source
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21
eLife, 2018 Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson +14 more
doaj +1 more source
The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule. [PDF]
PLoS Pathogens, 2010 Hepatitis C virus (HCV), a major cause of chronic liver disease in humans, is the focus of intense research efforts worldwide. Yet structural data on the viral envelope glycoproteins E1 and E2 are scarce, in spite of their essential role in the viral ...
Thomas Krey +13 more
doaj +1 more source
Exploring the Implications and Methodologies of Securing the E2 Interface
2024 IEEE Future Networks World Forum (FNWF)This work emerges from the intensifying need to understand and address security issues in rapidly advancing technologies such as 5G and beyond, including open radio access network (O-RAN). The current paper provides an in-depth examination of the security aspects of the E2 interface within the O-RAN context.
Hubert Djuitcheu +4 more
openaire +1 more source
F1000Research, 2013 Envelope glycoproteins of Hepatitis C Virus (HCV) play an important role in the virus assembly and initial entry into host cells. Conserved charged residues of the E2 transmembrane (TM) domain were shown to be responsible for the heterodimerization with ...
Rahmad Akbar, Siti Azma Jusoh
doaj +1 more source
Unique epithelial expression of S100A calcium binding protein A7A in the endometrium at conceptus implantation in pigs [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective S100A7A, a member of the S100 protein family, is involved in various biological processes, including innate immunity, antimicrobial function, and epithelial tumorigenesis.
Soohyung Lee +5 more
doaj +1 more source
Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]
, 2012 Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J. +14 more
core +1 more source
Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors [PDF]
, 2010 Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined.
Christiane Brohm +25 more
core +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source