Results 31 to 40 of about 1,377,203 (295)

Structural basis for broad neutralization of hepatitis C virus quasispecies. [PDF]

PLoS ONE, 2011
Monoclonal antibodies directed against hepatitis C virus (HCV) E2 protein can neutralize cell-cultured HCV and pseudoparticles expressing envelopes derived from multiple HCV subtypes.
Pascal Lapierre, Myriam Troesch, Fernando Alvarez, Hugo Soudeyns   +3 more
doaj   +1 more source

A View of the E2-CD81 Interface at the Binding Site of a Neutralizing Antibody against Hepatitis C Virus [PDF]

Journal of Virology, 2015
ABSTRACT Hepatitis C virus (HCV) glycoprotein E2 is considered a major target for generating neutralizing antibodies against HCV, primarily due to its role of engaging host entry factors, such as CD81, a key cell surface protein associated with HCV entry.
Christine, Harman, Lilin, Zhong, Li, Ma, Peter, Liu, Lu, Deng, Zhong, Zhao, Hailing, Yan, Evi, Struble, Maria Luisa, Virata-Theimer, Pei, Zhang   +9 more
openaire   +2 more sources

Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein [PDF]

, 2010
The hypervariable region 1 (HVR1) comprising the first 27 aa of E2 glycoprotein is a target for neutralizing antibodies against hepatitis C virus (HCV), but the mechanisms of this neutralization in the cell-culture-infectious genotype 2a strain JFH1 ...
Dubuisson, J., J. Dubuisson, A. H. Patel, G. Vieyres, Patel, A.H., Vieyres, G.   +5 more
core   +1 more source

GISS-E2-1-G

, 2023
This archive contains downscaled daily data from the GISS-E2-1-G model for the historical (1980–2014) and future (2015–2099) periods. The compressed tar file can be expanded using the following command: tar zxvf GISS-E2-1-G.tar.gz Data availability ...
Thanh Ngo-Duc (7311449), Etienne Espagne (13382451), Long Trinh-Tuan (7311446), Quan Tran-Anh (13382448)   +3 more
core   +1 more source

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly [PDF]

, 2011
Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies of three distinct enzymes (E1–E3) and an accessory subunit, E3BP (E3-binding protein). Its icosahedral E2/
Swetha Vijayakrishnan, Byron, Olwyn, Lindsay, J., Gilbert, David, Cooper, Alan, Lindsay, J.G., Nutley, Margaret A, Philip Callow, Byron, O., Callow, P, David Gilbert, Kropholler, P., Callow, Philip, Byron, O, McGow, D., Vijayakrishnan, S, David, Gilbert, Vijayakrishnan, Swetha, McGow, Donna P., Nutley, M.A., Gilbert, D, Callow, P., Kropholler, P, Alan Cooper, Nutley, Margaret A., Cooper, A., Donna P. McGow, Lindsay, J Gordon, Nutley, M., Lindsay, J. Gordon, Cooper, A, J. Gordon Lindsay, Vijayakrishnan, S., McGow, DP, Margaret A. Nutley, Olwyn Byron, Kropholler, Peter, Peter Kropholler, Mcgow, Donna P, Lindsay, JG, Nutley, MA, McGow, D.P., Gilbert, D.   +42 more
core   +1 more source

CCHCR1 interacts specifically with the E2 protein of human papillomavirus type 16 on a surface overlapping BRD4 binding.

PLoS ONE, 2014
The Human Papillomavirus E2 proteins are key regulators of the viral life cycle, whose functions are commonly mediated through protein-protein interactions with the host cell proteome. We identified an interaction between E2 and a cellular protein called
Mandy Muller, Caroline Demeret
doaj   +1 more source

HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. [PDF]

PLoS ONE, 2013
A strategy for antiviral drug discovery is the elucidation and imitation of viral interference mechanisms. HIV-1 patients benefit from a coinfection with GB Virus C (GBV-C), since HIV-positive individuals with long-term GBV-C viraemia show better ...
Kristin Eissmann, Sebastian Mueller, Heinrich Sticht, Susan Jung, Peng Zou, Shibo Jiang, Andrea Gross, Jutta Eichler, Bernhard Fleckenstein, Heide Reil   +9 more
doaj   +1 more source

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.

PLoS Biology, 2021
Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require ...
Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman   +15 more
doaj   +1 more source

Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage [PDF]

International Journal of Molecular Sciences, 2021
Implantation consists of a complex process based on coordinated crosstalk between the endometrium and trophoblast. Furthermore, it is known that the microenvironment of this fetal–maternal interface plays an important role in the development of extravillous trophoblast cells.
Lin Peng, Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt   +9 more
openaire   +3 more sources

Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney

Cell Discovery, 2022
The α-keto acid dehydrogenase complex family catalyzes the essential oxidative decarboxylation of α-keto acids to yield acyl-CoA and NADH. Despite performing the same overarching reaction, members of the family have different component structures and ...
Shiheng Liu, Xian Xia, James Zhen, Zihang Li, Z. Hong Zhou   +4 more
doaj   +1 more source