Results 11 to 20 of about 34,656 (117)
Spatiotemporal expression and regulation of peptidase inhibitor 3 and secretory leukocyte protease inhibitor at the maternal–fetal interface in pigs [PDF]
Animal Bioscience, 2023 Objective Two serine protease inhibitors, peptidase inhibitor 3 (PI3) and secretory leukocyte protease inhibitor (SLPI), play important roles in protease inhibition and antimicrobial activity, but their expression, regulation, and function at the ...
Soohyung Lee +3 more
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Memorias do Instituto Oswaldo Cruz, 2010 The objective of this study is to understand the structural flexibility and curvature of the E2 protein of human papillomavirus type 18 using molecular dynamics (6 ns).
Raúl Isea +2 more
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Structural basis for broad neutralization of hepatitis C virus quasispecies. [PDF]
PLoS ONE, 2011 Monoclonal antibodies directed against hepatitis C virus (HCV) E2 protein can neutralize cell-cultured HCV and pseudoparticles expressing envelopes derived from multiple HCV subtypes.
Pascal Lapierre +3 more
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PLoS ONE, 2014 The Human Papillomavirus E2 proteins are key regulators of the viral life cycle, whose functions are commonly mediated through protein-protein interactions with the host cell proteome. We identified an interaction between E2 and a cellular protein called
Mandy Muller, Caroline Demeret
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HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. [PDF]
PLoS ONE, 2013 A strategy for antiviral drug discovery is the elucidation and imitation of viral interference mechanisms. HIV-1 patients benefit from a coinfection with GB Virus C (GBV-C), since HIV-positive individuals with long-term GBV-C viraemia show better ...
Kristin Eissmann +9 more
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PLoS Biology, 2021 Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require ...
Christopher E Smith +15 more
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Cell Discovery, 2022 The α-keto acid dehydrogenase complex family catalyzes the essential oxidative decarboxylation of α-keto acids to yield acyl-CoA and NADH. Despite performing the same overarching reaction, members of the family have different component structures and ...
Shiheng Liu +4 more
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Frontiers in Immunology, 2018 Estradiol (E2) plays a crucial and intricate role during pregnancy to mediate several aspects of the pregnancy process. A perplexing phenomenon in congenital toxoplasmosis is that the severity of Toxoplasma gondii (T.
Jingfan Qiu +11 more
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Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21
eLife, 2018 Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown ...
Claire Dickson +14 more
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The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule. [PDF]
PLoS Pathogens, 2010 Hepatitis C virus (HCV), a major cause of chronic liver disease in humans, is the focus of intense research efforts worldwide. Yet structural data on the viral envelope glycoproteins E1 and E2 are scarce, in spite of their essential role in the viral ...
Thomas Krey +13 more
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