Thermodynamic variations at the HPV E1-E2 interface correlate with clinical risk groups: an in-silico analysis. [PDF]
Virol JBackground Human Papillomavirus (HPV) infection is a leading cause of human cancers, including nearly all cases of cervical cancer. The viral life cycle and its associated oncogenic potential are critically dependent on the replication of the viral ...
Fletcher S, Biswas-Fiss EE, Biswas SB.
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Quantifying electrostatic control of docking and binding energetics in functional Cx36 gap junctions. [PDF]
Commun BiolConnexin36 (Cx36) is broadly expressed in neurons and serves as the principal protein that forms interneuronal gap junctions (GJs), also known as electrical synapses.
Wong RS +5 more
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TDTAC: a generalized time-dependent torsion angle correlation framework for resolving directional coordination in large biomolecular assemblies. [PDF]
Front Mol BiosciProteins function through coordinated, time-dependent conformational motions, yet conventional analyses often obscure how these dynamics propagate across complex assemblies. Here, we introduce a generalized Time-Dependent Torsion Angle Correlation (TDTAC)
Escobar Palacio C, Shen T, Chang CA.
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Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. [PDF]
PLoS ONE, 2017 The mucosa of the female reproductive tract plays a pivotal role in host defence. Pregnancy must alter immunological mechanisms at this interface to protect the conceptus.
Behnia S Lashkari, Dilly O C Anumba
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Inhibitors of apoptosis: expression and regulation in the endometrium during the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs [PDF]
Animal Bioscience, 2022 Objective Caspase-mediated apoptosis plays a crucial role in the regulation of endometrial and placental function in females. Caspase activity is tightly controlled by members of the inhibitors of apoptosis proteins (IAPs) family. However, the expression
Inkyu Yoo +4 more
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Reproductive Biology and Endocrinology, 2023 Background Decidual macrophages participate in immune regulation at the maternal–fetal interface. Abnormal M1/M2 polarization of decidual macrophages might predispose immune maladaptation in recurrent pregnancy loss (RPL).
Yiyun Lou +8 more
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Crystal Structure of a Ube2S-Ubiquitin Conjugate. [PDF]
PLoS ONE, 2016 Protein ubiquitination occurs through the sequential formation and reorganization of specific protein-protein interfaces. Ubiquitin-conjugating (E2) enzymes, such as Ube2S, catalyze the formation of an isopeptide linkage between the C-terminus of a ...
Sonja Lorenz +4 more
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Loop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade. [PDF]
PLoS ONE, 2012 The ubiquitin (Ub) system controls almost every aspect of eukaryotic cell biology. Protein ubiquitination depends on the sequential action of three classes of enzymes (E1, E2 and E3).
Elena Papaleo +5 more
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Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. [PDF]
PLoS Pathogens, 2017 The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challenging ...
Radhika Gopal +13 more
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Periovulatory follicular fluid levels of estradiol trigger inflammatory and DNA damage responses in oviduct epithelial cells. [PDF]
PLoS ONE, 2017 OBJECTIVE:Ovarian steroid hormones (mainly E2 and P4) regulate oviduct physiology. Serum-E2 acts on the oviduct epithelium from the basolateral cell compartment.
Sergio E Palma-Vera +2 more
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