Results 1 to 10 of about 34,097 (156)

Thermodynamic variations at the HPV E1-E2 interface correlate with clinical risk groups: an in-silico analysis [PDF]

Virology Journal
Background Human Papillomavirus (HPV) infection is a leading cause of human cancers, including nearly all cases of cervical cancer. The viral life cycle and its associated oncogenic potential are critically dependent on the replication of the viral ...
Sean Fletcher, Esther E. Biswas-Fiss, Subhasis B. Biswas   +2 more
doaj   +3 more sources

Quantifying electrostatic control of docking and binding energetics in functional Cx36 gap junctions [PDF]

Communications Biology
Connexin36 (Cx36) is broadly expressed in neurons and serves as the principal protein that forms interneuronal gap junctions (GJs), also known as electrical synapses.
Robert S. Wong, Zhiyuan Song, Yu T. Zheng, Honghong Chen, Haiqing Zhao, Donglin Bai   +5 more
doaj   +2 more sources

Security Threats to xApps Access Control and E2 Interface in O-RAN

IEEE Open Journal of the Communications Society
Open Radio Access Networks (O-RANs) represent a novel wireless access network architecture that decomposes traditional RAN functions and makes them openly accessible.
Cheng-Feng Hung, You-Run Chen, Chi-Heng Tseng, Shin-Ming Cheng   +3 more
doaj   +2 more sources

Towards Quantum-Safe O-RAN: Experimental Evaluation of ML-KEM-Based IPsec on the E2 Interface [PDF]

Future Internet
As Open Radio Access Network (O-RAN) deployments expand and adversaries adopt “store-now, decrypt-later” strategies, operators need empirical data on the cost of migrating critical control interfaces to post-quantum cryptography (PQC).
Mario Perera, Michael Mackay, Max Hashem Eiza, Alessandro Raschella, Nathan Shone, Mukesh Kumar Maheshwari   +5 more
doaj   +3 more sources

TDTAC: a generalized time-dependent torsion angle correlation framework for resolving directional coordination in large biomolecular assemblies [PDF]

Frontiers in Molecular Biosciences
Proteins function through coordinated, time-dependent conformational motions, yet conventional analyses often obscure how these dynamics propagate across complex assemblies. Here, we introduce a generalized Time-Dependent Torsion Angle Correlation (TDTAC)
Carolina Escobar Palacio, Tongye Shen, Chia-En A. Chang   +2 more
doaj   +2 more sources

Anomaly Detection for Mitigating xApp and E2 Interface Threats in O-RAN Near-RT RIC

IEEE Open Journal of the Communications Society
As 5G networks advance, the Open Radio Access Network (O-RAN) is crucial in enabling openness and fostering collaboration across the telecom industry.
Cheng-Feng Hung, Chi-Heng Tseng, Shin-Ming Cheng   +2 more
doaj   +2 more sources

The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection. [PDF]

PLoS Pathogens
Getah virus (GETV), a mosquito-borne alphavirus, poses an emerging threat to public health with its increasingly broad host spectrum. While glycosaminoglycans (GAGs) serve as critical attachment factors for many alphaviruses and the low-density ...
Xiangshu Qiu, Rongguang Lu, Jiaxin Tian, He Zhang, Jiyong Zhou, Mengsi Sun, Xinyu Cao, Xiangyu Zhu, Bocheng Liu, Qihui Yu, Yuanyuan Li, Hualei Wang, Ningyi Jin, Huijun Lu, Ning Shi   +14 more
doaj   +2 more sources

Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes [PDF]

Journal of Virology, 2022
Alphaviruses, which can cause disease when spread to humans by mosquitoes, have been classified as emerging pathogens, with infections occurring worldwide. The spikes on the surface of the alphavirus particle are absolutely required for the virus to enter a new host cell and initiate an infection.
Sophia C. Ren, Shefah A. Qazi, Brian Towell, Joseph C.-Y. Wang, Suchetana Mukhopadhyay   +4 more
openaire   +3 more sources

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin [PDF]

Nature Chemical Biology, 2013
Weak protein interactions between ubiquitin and the ubiquitin-proteasome system (UPS) enzymes that mediate its covalent attachment to substrates serve to position ubiquitin for optimal catalytic transfer. We show that a small-molecule inhibitor of the E2 ubiquitin-conjugating enzyme Cdc34A, called CC0651, acts by trapping a weak interaction between ...
Hao Huang, Derek F Ceccarelli, Stephen Orlicky, Daniel J St-Cyr, Amy Ziemba, Pankaj Garg, Serge Plamondon, Manfred Auer, Sachdev Sidhu, Anne Marinier, Gary Kleiger, Mike Tyers, Frank Sicheri   +12 more
openaire   +2 more sources

Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. [PDF]

PLoS ONE, 2017
The mucosa of the female reproductive tract plays a pivotal role in host defence. Pregnancy must alter immunological mechanisms at this interface to protect the conceptus.
Behnia S Lashkari, Dilly O C Anumba
doaj   +1 more source