e2's Survey on Values and Attitudes 2016
, 2019 Tutkimuksessa selvitettiin suomalaisten näkemyksiä keskusteluilmapiiristä ja sen vaikutuksista osallistumiseen. Samalla kartoitettiin vastaajien näkemyksiä yhteiskunnan ilmapiiristä, demokratiasta, hyvinvoinnista, turvallisuudesta, maahanmuutosta ...
Think Tank e2 +3 more
core +1 more source
Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ : prostaglandin E2 dependent proliferation of growth plate chondrocytes [PDF]
, 2006 Prostaglandin E2 (PGE2) plays an important role in bone development and metabolism. To interfere therapeutically in the PGE2 pathway, however, knowledge about the involved enzymes (cyclooxygenases) and receptors (PGE2 receptors) is essential.
Nüsing, Rolf M. +9 more
core +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2 [PDF]
, 2012 Background: Ubiquitin-dependent protein degradation is a critical step in key cell cycle events, such as metaphase-anaphase transition and mitotic exit.
Udvardy Andor +20 more
core +4 more sources
JMIR Serious Games, 2023 BackgroundArticulation disorder decreases the clarity of language and causes a decrease in children’s learning and social ability.
Seong-Yeol Kim +6 more
doaj +1 more source
The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]
, 2015 The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J. +8 more
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue
Life Science AllianceWe demonstrate that altering a single residue in the RING domain greatly impacts ubiquitin transfer ability of the RING E3 ligase; as a framework for verification, we combine functional, biophysical, structural, and cellular assays. RING family ubiquitin
Mark A Nakasone +7 more
doaj +1 more source
Prostaglandin E2metabolism in rat brain: Role of the blood-brain interfaces [PDF]
Cerebrospinal Fluid Research, 2008 Abstract Background Prostaglandin E2 (PGE2) is involved in the regulation of synaptic activity and plasticity, and in brain maturation. It is also an important mediator of the central response to inflammatory challenges.
Strazielle Nathalie +3 more
openaire +3 more sources
Cardiac characteristics of sham, OVX, OVX-E2 and OVX-E2-EX groups.
, 2018 Cardiac characteristics of sham, OVX, OVX-E2 and OVX-E2-EX groups.
Yi-Yuan Lin (6107192) +9 more
core +1 more source