Results 101 to 110 of about 135,650 (305)

TRIM5α as an E3 ubiquitin ligase

The FASEB Journal, 2009
Human immunodeficiency virus type1 (HIV‐1) efficiently infects susceptible cells and causes acquired immunodeficiency syndrome (AIDS) in humans. Although HIV can also enter the cells of Old World monkeys, it encounters a block before reverse transcription.
Makoto Tanaka, Keiko Yamauchi, Tetsu Kamitani   +2 more
openaire   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Parkin is protective against proteotoxic stress in a transgenic zebrafish model [PDF]

, 2010
Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial ...
van Bebber Frauke, Dominik Paquet, Winklhofer Konstanze F., Pilsl Anna, Fett, Mareike E., Christian Haass, Bettina Schmid, Anna Pilsl, Mareike E Fett, Frauke van Bebber, Jörg Tatzelt, Fett Mareike E., Paquet, Dominik, Konstanze F. Winklhofer, Schmid Bettina, Paquet Dominik, Haass, Christian, Schmid, Bettina, Tatzelt Jörg, Tatzelt, Jörg, Pilsl, Anna, Konstanze F Winklhofer, Winklhofer, Konstanze F., Haass Christian, Bebber, Frauke van, Mareike E. Fett   +25 more
core   +1 more source

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

, 2023
The Src homology 2 (SH2) domain recognises phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signalling.
Ryan, Casement, Rosaria, Gitto, Elvira, Bruno, Alessio, Ciulli, Dylan, Lynch, Andrea, Testa, Kevin, Haubrich, Beth, Forrester, Sarath, Ramachandran, Nikolai, Makukhin, Manjula, Nagala   +10 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

MG53/TRIM72: multi-organ repair protein and beyond

Frontiers in Physiology
MG53, a member of the tripartite motif protein family, possesses multiple functionalities due to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase properties.
Yong-Fei Wang, Yong-Fei Wang, Zi-Yi An, Zi-Yi An, Jian-Wen Li, Jian-Wen Li, Zi-Kai Dong, Zi-Kai Dong, Wei-Lin Jin, Wei-Lin Jin   +9 more
doaj   +1 more source

Workflow for E3 Ligase Ligand Validation for PROTAC Development [PDF]

Proteolysis targeting chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. The development of PROTACs has been mainly focused on using CRBN (Cereblon) and VHL (Von Hippel-Lindau ligase) E3 ligase ligands.
Knapp, Stefan, Berner, Nicola, Hoffmann, Lasse, Wolf, Elmar, Weckesser, Janik, Abdul Azeez, Kamal Rayees, Gehrtz, Paul, Mosler, Thorsten, Đikić, Ivan, Schwalm, Martin P, Adhikari, Bikash, Sivashanmugam, Saran Aswathaman, Němec, Václav, Schlesiger, Sarah, Wilhelm, Stephanie, Rathore, Rajeshwari, Miletić, Nebojša, Hartung, Ingo V, Holzmann, Hanna, Müller, Susanne, Müller, Juliane, Hoffmann, Marina E, Elson, Lewis, Kuster, Bernhard   +23 more
core   +1 more source

Design and synthesis of inhibitors of the E3 ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) as a treatment for lung remodeling in Pulmonary Arterial Hypertension (PAH)

, 2023
Design and synthesis of inhibitors of the E3 ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) as a treatment for lung remodeling in Pulmonary Arterial Hypertension (PAH) A series of selective SMURF1 ligase inhibitors have been identified ...
Sohal, Bindi, D'Souza, Anne-Marie, Smith, Nichola, Rynn, Caroline, Rowlands, David, Beerli, Rene, Guth-Gundel, Sabine, Cotesta, Simona, Lattmann, Rene, Williams, Gareth, Pulz, Robert, Shaw, Duncan, Troxler, Thomas J.   +12 more
core   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source