Results 161 to 170 of about 211,577 (291)

TRIM16: a context-dependent E3 ligase in autophagy, oxidative stress, and immune regulation - from cancer and systemic disease. [PDF]

Front Oncol
Dong H, Jiang J, Ni K, Ren Q, Yang X, Shang L, Cai B, Li L.   +7 more
europepmc   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Nuclear Magnetic Resonance-based fragment screen of the E3 ligase Fem-1 homolog B. [PDF]

Protein Sci
Katinas JM, Amporndanai K, Taylor AJ, Rose KL, Gareiss PC, Crespo RA, Phan J, Waterson AG, Fesik SW.   +8 more
europepmc   +1 more source

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

EMBO Reports, 2017
Ziheng Chen, Lei Liu, Qi Cheng, Yanjun Li, Hao Wu, Wei-lin Zhang, Yueying Wang, S. A. Sehgal, Sami Siraj, Xiao-hui Wang, Jun Wang, Yushan Zhu, Quan Chen   +12 more
semanticscholar   +1 more source

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination. [PDF]

Cell Signal
Tsai M, Koch D, Forchione A, Farkas L, El-Mergawy R, Londino JD, Mallampalli RK.   +6 more
europepmc   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency. [PDF]

New Phytol
Orr JN, Mittmann SU, Ramsay L, Lewandowska D, Barakate A, Macaulay M, McCallum N, Waugh R, Colas I.   +8 more
europepmc   +1 more source

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

Molecules and Cells, 2017
Chun-Song Yang, Kasey Jividen, Adam Spencer, Natalia M. Dworak, Li Ni, Luke T. Oostdyk, Mandovi Chatterjee, B. Kusmider, Brian J. Reon, Mahmut Parlak, V. Gorbunova, T. Abbas, Erin D. Jeffery, N. Sherman, B. Paschal   +14 more
semanticscholar   +1 more source