Results 171 to 180 of about 200,227 (256)

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by ...
N Gamage (9895226), YJ Choi (16371132), JU Jung (22380238), A Subasinghe (22089764), DK Haluwana (22057841), K Chathuranga (22089770), Y Seong (22380235), WA Gayan Chathuranga (22051877), P Rathnapala (22380232), A Weerawardhana (22380223), TH Kim (14462652), JS Lee (12018053)   +11 more
core  

The E3 ligase MKRN2 prevents DRiP accumulation in stress granules and maintains granulostasis. [PDF]

EMBO Rep
Amzallag E, Danino YM, Secco V, Carra S, Hornstein E.   +4 more
europepmc   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Photocross-linking activity-based probes to capture the dynamics of ubiquitin RING E3 ligase interactions. [PDF]

Biochem J
Chandler SF, Tatham MH, Branigan E, Nakasone MA, Makukhin N, Ciulli A, Hay RT.   +6 more
europepmc   +2 more sources

A unified platform for the rapid assembly of glutarimides for Cereblon E3 ligase modulatory drugs. [PDF]

Nat Commun
Whalley DM, Lorthioir O, Anderson NA, Braybrooke E, Coote SC, Demanze S, Douglas HL, Putra OD, Proctor K, Si Y, Staniland S, Stokes S, Woodhouse A.   +12 more
europepmc   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin-Mediated Degradation of SPTBN1. [PDF]

Adv Sci (Weinh)
Zu Y, Chen S, Chen J, Ruan L, Li B, Chu W, Huang S, Yu D, Tian J, Zhao Y, Han Y, Tang X, Ji Y.   +12 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Author Correction: Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. [PDF]

EMBO Rep
Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS.   +8 more
europepmc   +1 more source