Results 71 to 80 of about 211,577 (291)

E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity. [PDF]

PLoS ONE, 2012
Although an increased expression level of XIAP is associated with cancer cell metastasis, the underlying molecular mechanisms remain largely unexplored.
Jinyi Liu, Dongyun Zhang, Wenjing Luo, Jianxiu Yu, Jingxia Li, Yonghui Yu, Xinhai Zhang, Jingyuan Chen, Xue-Ru Wu, Chuanshu Huang   +9 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells

Bio-Protocol
Ubiquitination is a post-translational protein modification that regulates a vast majority of processes during protein homeostasis. The covalent attachment of ubiquitin is a highly regulated process carried out by the sequential action of the three ...
Urbi Mukhopadhyay, Sophie Levantovsky, Christian Behrends, Sagar Bhogaraju   +3 more
doaj   +1 more source

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Journal of Biomedical Science, 2018
Background The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development.
Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang, Chi-Chen Huang   +9 more
doaj   +1 more source

Mdm2 induces mono-ubiquitination of FOXO4. [PDF]

PLoS ONE, 2008
The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis.
Arjan B Brenkman, Peter L J de Keizer, Niels J F van den Broek, A G Jochemsen, Boudewijn M Th Burgering   +4 more
doaj   +1 more source

Natural variation and dosage of the HEI10 meiotic E3 ligase control Arabidopsis crossover recombination

Genes & Development, 2017
Here, Ziolkowski et al. combine high-throughput fluorescence methods to measure crossovers with natural Arabidopsis ecotypes in order to identify the first trans-acting modifier of meiotic recombination in plants.
Piotr A. Ziolkowski, Piotr A. Ziolkowski, Charles J. Underwood, Charles J. Underwood, Christophe Lambing, Marina Martinez-Garcia, Emma J. Lawrence, Liliana Ziolkowska, Catherine Griffin, Kyuha Choi, F. C. H. Franklin, R. Martienssen, I. Henderson   +12 more
semanticscholar   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

Nature Communications, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
Anthea Di Rita, A. Peschiaroli, Pasquale D’Acunzo, D. Strobbe, Zehan Hu, Jens Gruber, Mads Nygaard, M. Lambrughi, G. Melino, Elena Papaleo, J. Dengjel, S. El Alaoui, M. Campanella, V. Dötsch, V. Rogov, F. Strappazzon, F. Cecconi   +16 more
semanticscholar   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

Nature Communications, 2019
Autophagy is an essential self-digestion machinery for cell survival and homoeostasis. Membrane elongation is fundamental, as it drives the formation of the double-membrane vesicles that engulf cytosolic material.
Aurora Scrivo, P. Codogno, P. Bomont
semanticscholar   +1 more source