Results 51 to 60 of about 197,780 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Rational Design and Synthesis of HSF1-PROTACs for Anticancer Drug Development

Molecules, 2022
PROTACs employ the proteosome-mediated proteolysis via E3 ligase and recruit the natural protein degradation machinery to selectively degrade the cancerous proteins. Herein, we have designed and synthesized heterobifunctional small molecules that consist
Chiranjeev Sharma, Myeong A Choi, Yoojin Song, Young Ho Seo   +3 more
doaj   +1 more source

WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets [PDF]

, 2011
A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation ...
Chantry, A
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells

Molecules
MDM2 and MDM4 are major negative regulators of tumor suppressor p53. Beyond regulating p53, MDM2 possesses p53-independent activity in promoting cell cycle progression and tumorigenesis via its RING domain ubiquitin E3 ligase activity. MDM2 and MDM4 form
Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang   +7 more
doaj   +1 more source

Structural basis of PROTAC cooperative recognition for selective protein degradation [PDF]

, 2017
Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to ...
A Illendula, A Thompson, A Whitty, AC Lai, AC Lai, AJ McCoy, Alessio Ciulli, Andrea Testa, AW Schüttelkopf, BR Brooks, C Galdeano, CE Stebbins, DM Duda, Douglas J Lamont, DP Bondeson, E Bulatov, E Krissinel, E Nicodeme, EF Douglass Jr., ES Fischer, ES Fischer, G Lu, G Petzold, GE Winter, GN Murshudov, J Frost, J Krönke, J Lu, J Zuber, J-H Min, JC Phillips, JM Roberts, K Raina, K Vanommeslaeghe, KM Sakamoto, Kwok-Ho Chan, LB Sheard, LL Manza, M Gilar, M Tanaka, M Toure, M Zengerle, M Zhou, MD Winn, ME Matyskiela, Michael Zengerle, MJ Waring, Morgan S Gadd, NM Glykos, P Emsley, P Filippakopoulos, P Filippakopoulos, P Thiel, PP Chamberlain, PR Evans, RA Laskowski, RJ Deshaies, RM Eglen, T Ito, VB Chen, W Humphrey, W Kabsch, W-C Hon, Wenzhang Chen, X Huang, X Tan, Xavier Lucas, Y Pommier   +67 more
core   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Pharmacophore-based ML model to filter candidate E3 ligands and predict E3 Ligase binding probabilities

Informatics in Medicine Unlocked
Among the plethora of E3 Ligases, only a few have been utilized for the novel PROTAC technology. However, extensive knowledge of the preparation of E3 ligands and their utilization for PROTACs is already present in several databases.
Reagon Karki, Yojana Gadiya, Simran Shetty, Philip Gribbon, Andrea Zaliani   +4 more
doaj   +1 more source

TRIM proteins legitimately enter the MAGEic RING [PDF]

, 2015
Comment on 'The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex' [Cell Cycle ...
Meroni, Germana, Zanchetta, MELANIA EVA
core   +1 more source