Results 41 to 50 of about 194,539 (300)

E3 ligase IpaH1.4/2.5 [PDF]

, 2023
Pathogenic bacteria deliver virulence factors called effectors into host cells in order to facilitate infection. The Shigella effector proteins IpaH1.4 and IpaH2.5 are members of the “novel E3 ligase” (NEL)-type bacterial E3 ligase family. These proteins
Takagi, Kenji, Keito Hiragi, Hiragi, Keito, Kazuhiro Iwai, Akira Nishide, Kim, Minsoo, Nishide, Akira, Minsoo Kim, Tsunehiro Mizushima, Kenji Takagi, Iwai, Kazuhiro, Mizushima, Tsunehiro   +11 more
core   +1 more source

Ubiquitin E3 ligase activity of Ralstonia solanacearum effector RipAW is not essential for induction of plant defense in Nicotiana benthamiana

Frontiers in Microbiology, 2023
As one of the most destructive bacterial phytopathogens, Ralstonia solanacearum causes substantial annual yield losses of many important crops. Deciphering the functional mechanisms of type III effectors, the crucial factors mediating R.
Xue Ouyang, Jialan Chen, Zhimao Sun, Rongbo Wang, Xuan Wu, Benjin Li, Congfeng Song, Peiqing Liu, Meixiang Zhang   +8 more
doaj   +1 more source

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains [PDF]

, 2015
This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin ...
Naismith, Jim, Emma Branigan, Branigan, Emma, Hay, Ronald T., Ellis G Jaffray, Plechanovová, Anna, Jaffray, Ellis, Jaffray, Ellis G., Naismith, James H., James H Naismith, Hay, Ronald Thomas, Anna Plechanovová, Ronald T Hay   +12 more
core   +1 more source

Inhibiting E3 ligases [PDF]

Science-Business eXchange, 2010
Two groups of researchers have identified inhibitors of E3 ubiquitin ligase, which has been considered difficult, if not impossible, to target with small molecules. The findings could lead to compounds that are more specific disrupters of tumor cell proliferation than the proteasome inhibitor Velcade bortezomib.
openaire   +1 more source

Entropy-Driven Mechanism of an E3 Ligase [PDF]

Biochemistry, 2011
Ubiquitin-like modifications are macromolecular chemistry for which our understanding of the enzymatic mechanisms is lacking. Most E3 ligases in ubiquitin-like modifications do not directly participate in chemistry but are thought to confer allosteric effects; however, the nature of the allosteric effects has been elusive.
Khue, Truong, Yang, Su, Jing, Song, Yuan, Chen   +3 more
openaire   +2 more sources

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source

A pathogen type III effector with a novel E3 ubiquitin ligase architecture.

PLoS Pathogens, 2013
Type III effectors are virulence factors of Gram-negative bacterial pathogens delivered directly into host cells by the type III secretion nanomachine where they manipulate host cell processes such as the innate immunity and gene expression.
Alexander U Singer, Sebastian Schulze, Tatiana Skarina, Xiaohui Xu, Hong Cui, Lennart Eschen-Lippold, Monique Egler, Tharan Srikumar, Brian Raught, Justin Lee, Dierk Scheel, Alexei Savchenko, Ulla Bonas   +12 more
doaj   +1 more source

Genome-wide identification and transcriptome profiling reveal that E3 ubiquitin ligase genes relevant to ethylene, auxin and abscisic acid are differentially expressed in the fruits of melting flesh and stony hard peach varieties

BMC Genomics, 2019
Background Ubiquitin ligases (E3) are the enzymes in the ubiquitin/26S proteasome pathway responsible for targeting proteins to the degradation pathway and play major roles in multiple biological activities. However, the E3 family and their functions are
Bin Tan, Xiaodong Lian, Jun Cheng, Wenfang Zeng, Xianbo Zheng, Wei Wang, Xia Ye, Jidong Li, Zhiqian Li, Langlang Zhang, Jiancan Feng   +10 more
doaj   +1 more source

TRIM32 is an E3 ubiquitin ligase for dysbindin [PDF]

Human Molecular Genetics, 2009
Mutations in the gene encoding tripartite motif protein 32 (TRIM32) cause two seemingly diverse diseases: limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11(BBS11). Although TRIM32 is involved in protein ubiquitination, its substrates and the molecular consequences of disease-causing ...
Locke, Matthew, Tinsley, Caroline L., Benson, Matthew A., Blake, Derek J.   +3 more
openaire   +3 more sources

Trim25 restricts rabies virus replication by destabilizing phosphoprotein

Cell Insight, 2022
Tripartite motif-containing protein 25 (Trim25) is an E3 ubiquitin ligase that activates retinoid acid-inducible gene I (RIG-I) and promotes the antiviral interferon response.
Yueming Yuan, An Fang, Zongmei Wang, Bin Tian, Yuan Zhang, Baokun Sui, Zhaochen Luo, Yingying Li, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao   +11 more
doaj   +1 more source