Results 21 to 30 of about 135,650 (305)

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis [PDF]

, 2015
The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encodes parkin, an E3 ubiquitin ligase of the RBR family.
R Julio Martinez‐Torres, Shaw, Gary S., Kathryn R Barber, Knebel, Axel, Aguirre, Jacob D., Spratt, Donald E., Axel Knebel, Chaugule, Viduth K., Mercier, Pascal, Viduth K Chaugule, Condos, Tara E. C., Jacob D Aguirre, Pascal Mercier, Barber, Kathryn R., Rachel Toth, Ramasubramanian Sundaramoorthy, Helen Walden, Toth, Rachel, Gary S Shaw, Tara EC Condos, Walden, Helen, Condos, Tara E.C., Martinez-Torres, R. Julio, Donald E Spratt, Kumar, Atul, Sundaramoorthy, Ramasubramanian, Atul Kumar   +26 more
core   +1 more source

Activation of the E3 ubiquitin ligase Parkin [PDF]

Biochemical Society Transactions, 2015
The PINK1 (phosphatase and tensin homologue-induced putative kinase 1)/Parkin-dependent mitochondrial quality control pathway mediates the clearance of damaged organelles, but appears to be disrupted in Parkinson's disease (PD) [Springer and Kahle (2011) Autophagy 7, 266–278].
Thomas R, Caulfield, Fabienne C, Fiesel, Wolfdieter, Springer   +2 more
openaire   +2 more sources

SUMO chain-induced dimerization activates RNF4 [PDF]

, 2014
Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Hay, Ronald T, Rojas-Fernandez, Alejandro, Hattersley, Neil, Plechanovová, Anna, Tatham, Michael H, Jaffray, Ellis   +5 more
core   +1 more source

Pharmacophore-based ML model to predict ligand selectivity for E3 ligase binders

, 2023
E3 ligases are enzymes that play a critical role in ubiquitin-mediated protein degradation and are involved in various cellular processes. Pharmacophore analysis is a useful approach for predicting E3 ligase binding selectivity, which involves ...
Andrea, Zaliani, Reagon, Karki, Philip , Gribbon, Yojana, Gadiya   +3 more
core   +1 more source

Pto kinase binds two domains of AvrPtoB and its proximity to the effector E3 ligase determines if it evades degradation and activates plant immunity. [PDF]

PLoS Pathogens, 2014
The tomato--Pseudomonas syringae pv. tomato (Pst)--pathosystem is one of the best understood models for plant-pathogen interactions. Certain wild relatives of tomato express two closely related members of the same kinase family, Pto and Fen, which ...
Johannes Mathieu, Simon Schwizer, Gregory B Martin   +2 more
doaj   +1 more source

The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]

, 2013
Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core   +1 more source

Inhibiting E3 ligases [PDF]

Science-Business eXchange, 2010
Two groups of researchers have identified inhibitors of E3 ubiquitin ligase, which has been considered difficult, if not impossible, to target with small molecules. The findings could lead to compounds that are more specific disrupters of tumor cell proliferation than the proteasome inhibitor Velcade bortezomib.
openaire   +1 more source

Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1 [PDF]

, 2010
Fungal and oomycete plant pathogens translocate effector proteins into host cells to establish infection. However, virulence targets and modes of action of their effectors are unknown.
Hein, I., Dixelius, Christina, Hein, I, Hein, Ingo, Bryan, G, Dixelius, C., Kamoun, S., Gilroy, EM, Bos, JIB, Sadanandom, A, Boevink, PC, Gilroy, Eleanor M., Armstrong, MR, Bos, J. I. B., Taylor, RM, Bos, Jorunn I. B., Zhendong, T., Sadanandom, A., Boevink, Petra C., Dixelius, C, Engelhardt, Stefan, Bryan, Glenn, Birch, PRJ, Armstrong, M. R., Engelhardt, S, Hein, Ingo; id_orcid, Harrower, Brian, Kamoun, Sophien, Whisson, Stephen C., Vetukuri, R. R., Birch, Paul R. J.; id_orcid, Bryan, G., Vetukuri, RR, Engelhardt, S., Whisson, S. C., Tian, ZD, Whisson, SC, Boevink, P. C., Bryan, Glenn J., Bos, Jorunn, Gilroy, E. M., Sadanandom, Ari, Birch, Paul R. J., Harrower, B., Harrower, B, Vetukuri, Ramesh R., Birch, P. R. J., Taylor, R. M., Armstrong, Miles R., Taylor, Rosalind M., Zhendong, Tian, Kamoun, S, Tian, Zhendong   +52 more
core   +1 more source

Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads

BMC Pharmacology and Toxicology, 2017
Background Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum.
Jagrati Jain, Surendra K. Jain, Larry A. Walker, Babu L. Tekwani   +3 more
doaj   +1 more source

Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1

Biochemistry and Biophysics Reports, 2020
TRIM family of E3 ubiquitin ligases have an amino-terminal conserved tripartite motif consisting of RING, B-Box, coiled-coil domain and different C-terminal domain leading it to classification into 11 subclasses.
Ishita Gupta, Shreya Dharadhar, Titia Sixma, Sameena Khan   +3 more
doaj   +1 more source