Results 31 to 40 of about 200,227 (256)

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains [PDF]

, 2015
This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin ...
Naismith, Jim, Emma Branigan, Branigan, Emma, Hay, Ronald T., Ellis G Jaffray, Plechanovová, Anna, Jaffray, Ellis, Jaffray, Ellis G., Naismith, James H., James H Naismith, Hay, Ronald Thomas, Anna Plechanovová, Ronald T Hay   +12 more
core   +1 more source

Genome-Wide Identification of the U-Box E3 Ubiquitin Ligase Gene Family in Cabbage (Brassica oleracea var. capitata) and Its Expression Analysis in Response to Cold Stress and Pathogen Infection

Plants, 2023
Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses in many species. However, the characteristics of U-box E3 ubiquitin ligase genes in cabbage (Brassica oleracea var.
Peiwen Wang, Lin Zhu, Ziheng Li, Mozhen Cheng, Xiuling Chen, Aoxue Wang, Chao Wang, Xiaoxuan Zhang   +7 more
doaj   +1 more source

E3 ligase IpaH1.4/2.5 [PDF]

, 2023
Pathogenic bacteria deliver virulence factors called effectors into host cells in order to facilitate infection. The Shigella effector proteins IpaH1.4 and IpaH2.5 are members of the “novel E3 ligase” (NEL)-type bacterial E3 ligase family. These proteins
Takagi, Kenji, Keito Hiragi, Hiragi, Keito, Kazuhiro Iwai, Akira Nishide, Kim, Minsoo, Nishide, Akira, Minsoo Kim, Tsunehiro Mizushima, Kenji Takagi, Iwai, Kazuhiro, Mizushima, Tsunehiro   +11 more
core   +1 more source

A pathogen type III effector with a novel E3 ubiquitin ligase architecture.

PLoS Pathogens, 2013
Type III effectors are virulence factors of Gram-negative bacterial pathogens delivered directly into host cells by the type III secretion nanomachine where they manipulate host cell processes such as the innate immunity and gene expression.
Alexander U Singer, Sebastian Schulze, Tatiana Skarina, Xiaohui Xu, Hong Cui, Lennart Eschen-Lippold, Monique Egler, Tharan Srikumar, Brian Raught, Justin Lee, Dierk Scheel, Alexei Savchenko, Ulla Bonas   +12 more
doaj   +1 more source

Genome-wide identification and transcriptome profiling reveal that E3 ubiquitin ligase genes relevant to ethylene, auxin and abscisic acid are differentially expressed in the fruits of melting flesh and stony hard peach varieties

BMC Genomics, 2019
Background Ubiquitin ligases (E3) are the enzymes in the ubiquitin/26S proteasome pathway responsible for targeting proteins to the degradation pathway and play major roles in multiple biological activities. However, the E3 family and their functions are
Bin Tan, Xiaodong Lian, Jun Cheng, Wenfang Zeng, Xianbo Zheng, Wei Wang, Xia Ye, Jidong Li, Zhiqian Li, Langlang Zhang, Jiancan Feng   +10 more
doaj   +1 more source

Trim25 restricts rabies virus replication by destabilizing phosphoprotein

Cell Insight, 2022
Tripartite motif-containing protein 25 (Trim25) is an E3 ubiquitin ligase that activates retinoid acid-inducible gene I (RIG-I) and promotes the antiviral interferon response.
Yueming Yuan, An Fang, Zongmei Wang, Bin Tian, Yuan Zhang, Baokun Sui, Zhaochen Luo, Yingying Li, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao   +11 more
doaj   +1 more source

Author Correction: Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP [PDF]

, 2021
Author Correction to "Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase ...
Cheng, Yuan, Xu, Yu-ming, Li, Yu-sheng, Hu, Zheng-wei, Li, Shao-hua, Zhang, Shuo, Schisler, Jonathan C., Luo, Hai-yang, Shi, Chang-he, Mao, Cheng-yuan, Tang, Mi-bo   +10 more
core   +1 more source

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

Nature Communications, 2017
Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly.
Yang Li, Ping Xie, Liang Lu, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li, Fuchu He   +12 more
doaj   +1 more source

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light [PDF]

, 2019
A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s ...
Maria M., Shchepinova, Edward, Tate, Cyrille, Kounde   +2 more
core   +2 more sources

SIAH1 (siah E3 ubiquitin protein ligase 1) [PDF]

, 2013
Review on SIAH1 (siah E3 ubiquitin protein ligase 1), with data on DNA, on the protein encoded, and where the gene is ...
Nagano, Y, Matsuzawa, SI
core   +1 more source