Results 11 to 20 of about 197,780 (305)
ITCH E3 ligase in ATM network [PDF]
Oncoscience, 2014 Ataxia Telangiectasia Mutated (ATM) kinase is a central regulator of the DNA damage response and its loss of function leads to the development of Ataxia Telangiectasia, a rare genetic disorder characterized by several features among which cerebellar neuron degeneration which causes ataxia, telangiectasia, immune system abnormalities, higher ...
Stagni, V, Santini, S, BARILA', DANIELA
openaire +6 more sources
"Cullin 4 makes its mark on chromatin" [PDF]
Cell Division, 2006 Cullin 4 (Cul4), a member of the evolutionally conserved cullin protein family, serves as a scaffold to assemble multisubunit ubiquitin E3 ligase complexes.
Wang Hengbin, Dai Qian
doaj +2 more sources
MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4 [PDF]
, 2015 Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy.
A Gembarska +63 more
core +18 more sources
Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer
Pathology and Oncology Research, 2023 Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis ...
Aiqin Sun +5 more
doaj +1 more source
PLoS Genetics, 2023 The tumor suppressor BRCA1-BARD1 complex regulates many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity.
Qianyan Li +4 more
doaj +1 more source
Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome
Life Science Alliance, 2022 The authors use photocrosslinking activity-based probes to monitor RNF12/RLIM E3 ubiquitin ligase activity and report the impact of Tonne-Kalscheuer syndrome (TOKAS) patient variants on catalysis.
Francisco Bustos +6 more
doaj +1 more source
CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. [PDF]
PLoS ONE, 2015 The CUL4-DDB1 E3 ligase complex serves as a critical regulator in various cellular processes, including cell proliferation, DNA damage repair, and cell cycle progression.
Xin Tong +6 more
doaj +1 more source
PROTACs: A novel strategy for cancer drug discovery and development
MedComm, 2023 Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists of three components: a small molecule that binds to a target protein, an ...
Xin Han, Yi Sun
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The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. [PDF]
PLoS ONE, 2011 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via translocated ...
Heather Piscatelli +7 more
doaj +1 more source
Structural Diversity of Ubiquitin E3 Ligase [PDF]
Molecules, 2021 The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes. Three enzymes are required for achieving the ubiquitination reaction: ubiquitin-activating enzyme (E1),
Toma-Fukai, Sachiko, Shimizu, Toshiyuki
openaire +3 more sources