Results 141 to 150 of about 504,547 (295)

Identification of ligands for E3 ligases with restricted expression using fragment-based methods

RSC Chemical Biology
NMR-based screening identified fragment hits that bind to E3 ligases that are preferentially expressed in cancer tissues.
Alex G. Waterson, Brian D. Lehmann, Zhenwei Lu, John L. Sensintaffar, Edward T. Olejniczak, Bin Zhao, Tyson Rietz, William G. Payne, Jason Phan, Stephen W. Fesik   +9 more
openaire   +3 more sources

Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation

Nature Communications
As a crucial element of proteolysis targeting chimeras (PROTACs), the choice of E3 ubiquitin ligase significantly influences degradation efficacy and selectivity. However, the available arsenal of E3 ligases for PROTAC development remains underexplored, severely limiting the scope of targeted protein degradation.
Zhihao Yang, Miao Chen, Ruixin Ge, Ping Zhou, Wei Pan, Jiayi Song, Shuwen Ma, Song Chen, Chenyu Xu, Mengyu Zhou, Wenyi Mi, Hua Ni, He Chen, Xue Yao, Xifeng Dong, Yan Chen, Jun Zhou, Chenghao Xuan, Cheng Dong, Hua Yan, Songbo Xie   +20 more
openaire   +3 more sources

The intracellular domains of the DSL ligands Serrate and Delta provide different activities

Cell Communication and Signaling
Endocytosis of the ligands is a central requirement for the correct activation of the Notch-signalling pathway. It is initiated by E3-ligase mediated ubiquitylation (ubi) of the intracellular domain (ICD) of the ligands on lysine (K).
Ekaterina Seib, Maya Schmid, Hideyuki Shimizu, Tobias Troost, Sunday Faith Oyelere, Biswajit Chakraborty, Martin Baron, Thomas Klein   +7 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science
Targeted protein degradation (TPD) offers powerful therapeutic opportunities but is limited by poor tissue penetration and E3 ligase dependence. Herein, we develop Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC), an ultrasound (US)‐activated ...
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
doaj   +1 more source

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]

, 2018
Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core  

In vitro SUMOylation assay to study SUMO E3 ligase activity

, 2018
[[abstract]]Small ubiquitin-like modifier (SUMO) modification is an important post-translational modification (PTM) that mediates signal transduction primarily through modulating protein-protein interactions.
Yang, WS;Campbell, M;Kung, HJ;Chang, PC
core   +1 more source

Comparative Analysis of Salmonella typhimurium‐Induced Transcriptomic Changes in the Spleen of Beijing‐You Chickens and Guang Ming Broilers

Animal Research and One Health, EarlyView.
This study analyzed the spleen transcriptomes of different chicken breeds, identified key differentially expressed genes (EGR1, FOS, and DUSP1) that regulate resistance to Salmonella infection, and elucidated the underlying regulatory mechanisms, thereby providing new targets for disease‐resistant breeding in poultry.
Zixuan Wang, Man Deng, He Geng, Jumei Zheng, Xiang Li, Yaping Wang, Qinghe Li, Guiping Zhao, Qiao Wang   +8 more
wiley   +1 more source

Proteolysis-targeting chimera (PROTAC) in cancer: design principles and applications on “undruggable” targets

Biomarker Research
Targeted cancer therapies can enhance in vivo efficacy and decrease side effects by changing the distribution and exposure of specific biomolecules in tissues.
Xun Lu, Jianliang Qin, Shuilin Dong, Yue Yuan, Zhanguo Zhang, Bixiang Zhang, Xiaoping Chen, Xiaoli Gan, Huifang Liang, Furong Liu   +9 more
doaj   +1 more source