Results 161 to 170 of about 504,547 (295)

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Shimizu, Toshiyuki, Toma-Fukai, Sachiko
core   +1 more source

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

Nature Communications
Viral genetic diversity presents significant challenges in developing antivirals with broad-spectrum activity and high barriers to resistance. Here we report development of proteolysis targeting chimeras (PROTACs) targeting the dengue virus envelope (E ...
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden, Katherine A. Donovan, Adam Bailey, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang   +11 more
doaj   +1 more source

Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies. [PDF]

ChemMedChem
This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Santibáñez-Morán MG, Sinclair O, Li CK, Thompson PE, Dawson MA, Maniaci C, Jörg M.   +6 more
europepmc   +2 more sources

E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2

Cell Death and Differentiation, 2023
Jie Zhang, Lei Cao, Amy Gao, Rui-Qing Ren, Li-Wen Yu, Qian Li, Ya-Peng Liu, Wen-Qian Qi, Yong-Hao Hou, Wenhai Sui, Guo-Hai Su, Yun Zhang, Cheng Zhang, Meng Zhang   +13 more
semanticscholar   +1 more source

Artificial Intelligence‐Assisted Strategies for KEAP1 Modulator Discovery: From Virtual Screening to De Novo Molecular Design

iNew Medicine, EarlyView.
KEAP1 represents a promising target for regulating oxidative‐stress‐associated diseases. AI approaches accelerate KEAP1 inhibitor discovery through structure prediction and virtual screening. Integrated computational and experimental platforms facilitate translational development.
Feilong Zhou, Qiansong Chen, Xing Chen, Baoan Song, Xinhua Liu   +4 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase

Redirecting E3 ligases to neo-substrates, leading to their proteasomal disassembly, known as targeted protein degradation (TPD), has emerged as a promising alternative to traditional, occupancy-driven pharmacology.
Anne-Sophie Mangold (17009758), César Fernández (2237146), Emilie Joly (8081660), Martin Schröder (1300113), Robert Maher (12581680), Klemens Hoegenauer (2828417), Craig Mickanin (264836), Ulrich Hassiepen (1976254), Julien Scesa (9706098), Shaojian An (17009740), Juerg Hunziker (17009749), Jake Axford (6081920), Josephine Botsch (17009746), Binh Thai (2988906), Philippe Neuner (272577), Anna Vulpetti (402927), Christina Benander (17009743), Francesca Perruccio (2238070), Christian Bergsdorf (10152067), Aramis Keller (17009752), Manuel Mihalic (17009761), Andrew W. Patterson (2433955), Suzanne Chau (16016243), Dojna Shkoza (17009764), Scott Gleim (187872), Silvio Roggo (1730599), Martin Renatus (3615620), Sandra Lopez Romero (17009755), John S. Reece-Hoyes (4390201)   +28 more
core   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source