Results 181 to 190 of about 504,547 (295)

Salidroside Alleviates AlCl3/D‐galactose‐Induced Alzheimer's Disease‐Like Mice Neuronal Damage and Synaptic Dysfunction Through Keap1/Nrf2/GSH Signaling Axis

Phytotherapy Research, EarlyView.
Salidroside alleviates AlCl3/D‐galactose‐induced neuronal injury and synaptic dysfunction in AD‐like mice via regulation of the Keap1/Nrf2/GSH signaling axis. ABSTRACT Alzheimer's disease (AD) is associated with glutathione (GSH) depletion and redox imbalance in the brain, contributing to hippocampal neuronal damage and synaptic dysfunction and ...
Heying Cui, Yihua Han, Yanzhu Lu, Shuhua Zheng, Ruijing Zhang, Xianjing Zhang, Zheng Nan, Xiangdan Li, Songbiao Cui, Dongyuan Xu   +9 more
wiley   +1 more source

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders. [PDF]

ChemMedChem
Almodóvar-Rivera CM, Tandon I, Mudududdla R, Esguerra PN, Lucio-Acero K, Tang W.   +5 more
europepmc   +1 more source

Ganoderic Acids Alleviate Dexamethasone‐Induced Muscle Atrophy Potentially via Regulating Protein Synthesis/Degradation, Attenuating Oxidative Stress, and Antagonizing Glucocorticoid Receptor

Phytotherapy Research, EarlyView.
This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang, Yan Yu, Yiru Chen, Zhizhen Huang, Hang Zhang, Yun Tian, Min Li, Yue Yin, Shaowei Li, Bingchuan Liu, Baoxue Yang   +10 more
wiley   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

, 2016
Restoration of tumor suppression in prostate cancer by targeting the E3 ligase ...
RL Vessella (21784067), ED Williams (9893567), S Fox (7690490), C Gamell (9884090), C Fedele (21784124), AL Chan (21784115), PJ Paul (21784109), J Hagekyriakou (13716523), Y Haupt (9884102), M Shackleton (13425897), E Takano (21784121), D Raghu (21784112), T Gulati (21784118), S Williams (7727048), S Haupt (9884093), L Lambeth (13283382), MJ Herold (10752270)   +16 more
core  

Structural themes of cereblon‐recruiting degraders: selected recent examples

Acta Crystallographica Section F, EarlyView.
Structural studies of cereblon‐recruiting degrader complexes have transformed our understanding of targeted protein degradation. This review discusses selected examples of how X‐ray crystallography and cryogenic‐electron microscopy have enabled the structure‐guided optimization of heterobifunctional degraders and molecular‐glue degraders.
Sana Ahmed, Michael Rowley
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

miniPROTACs: Bridging PROTACs and molecular glues with a new degron alphabet. [PDF]

Acta Pharm Sin B
Wang J.
europepmc   +1 more source