Results 161 to 170 of about 72,591 (191)

Dueling E3 Ligases

Science's STKE, 2004
Protein degradation plays a key role in progression through the cell cycle. The anaphase-promoting complex (APC) is best known for its role as an E3 ubiquitin ligase that contributes to the degradation of proteins that allow exit from mitosis.
openaire   +1 more source

Autoantigen Ro52 is an E3 ubiquitin ligase

Biochemical and Biophysical Research Communications, 2006
Anti-Ro/SSA antibodies are classic autoantibodies commonly found in patients with Sjögren's syndrome, a chronic autoimmune disease characterized by dryness of the eyes and mouth. The autoantibodies recognize a RING-finger protein, Ro52, whose function is still unknown.
Keiji, Wada, Tetsu, Kamitani
openaire   +2 more sources

Pseudophosphatase as E3 ubiquitin ligase inhibitor

Science Signaling, 2017
The pseudophosphatase STYX prevents the substrate recognition subunit FBXW7 from binding the catalytic E3 ubiquitin ligase complex.
openaire   +2 more sources

HECT-Type E3 Ubiquitin Ligases in Cancer

Trends in Biochemical Sciences, 2019
Ubiquitination, a post-translational modification that involves a covalent attachment of ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and promote or directly catalyze ubiquitin transfer to targets.
Francesca Bernassola, Giovanni Chillemi, Gerry Melino   +2 more
openaire   +4 more sources

E3 ubiquitin ligase that recognizes sugar chains

Nature, 2002
N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-linked high-mannose oligosaccharides
Yukiko, Yoshida, Tomoki, Chiba, Fuminori, Tokunaga, Hiroshi, Kawasaki, Kazuhiro, Iwai, Toshiaki, Suzuki, Yukishige, Ito, Koji, Matsuoka, Minoru, Yoshida, Keiji, Tanaka, Tadashi, Tai   +10 more
openaire   +2 more sources

Notch Interacts with an E3 Ligase

Science Signaling, 2001
The membrane protein Notch transduces signals from the cell surface to the transcription machinery by deploying its cleaved intracellular (IC) domain to the nucleus. It is less clear how Notch action is turned off once its mission is fulfilled in the nucleus.
openaire   +2 more sources

Discovery, characterization and engineering of ligases for amide synthesis

Nature, 2021
Michael Winn, Fanghua Wang, Luis Bering   +2 more
exaly  

E3 Ubiquitin Ligases

2012
Uwe Proske, David L. Morgan, Tamara Hew-Butler, Kevin G. Keenan, Roger M. Enoka, Sebastian Sixt, Josef Niebauer, John A. Hawley, Martin J. Gibala, Kathryn H. Myburgh, C. Capelli, P. Zamparo, Jie Kang, Herbert Löllgen, Ruth Löllgen, Wolfgang Jelkmann, Christopher B. Scott, Ioannis Smyrnias, Martin D. Bootman, H. Llewelyn Roderick, Jonathan N. Myers, Peter H. Brubaker, Kai-Håkon Carlsen, Michael Kjær, Marc Sim, Peter Peeling, Brian Dawson, Debbie Trinder   +27 more
openaire   +1 more source

E3-Ubiquitin Ligase

2011
openaire   +2 more sources

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Nature Reviews Molecular Cell Biology, 2016
Lori Buetow, Danny T Huang
exaly