Results 181 to 190 of about 105,668 (286)

In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation. [PDF]

J Am Chem Soc
Zheng Y, Singh A, Niu Z, Marin V, Young J, Richardson P, Hemshorn ML, Cooley RB, Karplus PA, Puvar K, Warder SE, Vasudevan A, Reitsma JM, Mehl RA.   +13 more
europepmc   +1 more source

Regulation of inflammation and immunity in sepsis by E3 ligases. [PDF]

Front Endocrinol (Lausanne), 2023
Shao S, Zhou D, Feng J, Liu Y, Baturuhu, Yin H, Zhan D.   +6 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

An alternative pocket for binding the N-degrons by the UBR1 and UBR2 ubiquitin E3 ligases. [PDF]

Protein Sci
Huang ST, Chen DH, Ren T, Thomas N, Wu J, Sankaran B, Jones R, Taylor S, Chen Y.   +8 more
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity. [PDF]

Nat Commun
Schwartz I, Budroni V, Meyenberg M, Hodakova Z, Hornegger H, Hacker K, Schwartz S, Grabarczyk DB, Ehrmann JF, Scinicariello S, Haselbach D, Menche J, Clausen T, Karagöz GE, Versteeg GA.   +14 more
europepmc   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

A 'Candidatus Liberibacter asiaticus' effector SDE2470 facilitates citrus transcription factor CsVOZ2 degradation via BRUTUS E3 ligases. [PDF]

PLoS Pathog
Fu S, Yang X, Zhao H, Yang Z, Wang J, Qin M, Zhou C, Wang X.   +7 more
europepmc   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells. [PDF]

Adv Sci (Weinh)
Cui D, Qu R, Li T, Wang L, Chen X, Shao S, Liang X, Xu J, Sun Y, Xiong X, Zhao Y.   +10 more
europepmc   +1 more source