Results 201 to 210 of about 47,607 (250)

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Genetic retargeting of E3 ligases to enhance CAR T cell therapy. [PDF]

Cell Chem Biol
Lane IC, Kembuan G, Carreiro J, Kann MC, Lin W, Bouffard AA, Kreuzer J, Morris R, Schneider EM, Kim JY, Zou C, Salas-Benito D, Gasser JA, Leick MB, Słabicki M, Haas W, Maus MV, Jan M.   +17 more
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. [PDF]

J Cell Biol
Shimshon A, Dahan K, Israel-Gueta M, Olmayev-Yaakobov D, Timms RT, Bekturova A, Makaros Y, Elledge SJ, Koren I.   +8 more
europepmc   +1 more source

Genome-Wide Analysis of HECT E3 Ligases Members in Phyllostachys edulis Provides Insights into the Role of PeHECT1 in Plant Abiotic Stress Response. [PDF]

Int J Mol Sci
Xie X, Hu S, Liu L, Pan H, Huang H, Cao X, Qiao G, Han X, Qiu W, Lu Z, Zhuo R, Xu J.   +11 more
europepmc   +1 more source

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. [PDF]

Nucleic Acids Res
Zhu K, Suskiewicz MJ, Chatrin C, Strømland Ø, Dorsey BW, Aucagne V, Ahel D, Ahel I.   +7 more
europepmc   +1 more source

Deltex family E3 ligases specifically ubiquitinate the terminal ADP-ribose of poly(ADP-ribosyl)ation. [PDF]

Biochem Biophys Res Commun
Kelly M, Dietz C, Kasson S, Zhang Y, Holtzman MJ, Kim IK.   +5 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

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Inhibitors for E3 ubiquitin ligases

Nature Biotechnology, 2010
Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.
Harper J Wade
exaly   +2 more sources

E3 ligases team up

Nature Reviews Molecular Cell Biology, 2010
Katharine H Wrighton, Wrighton Katharine H   +1 more
exaly   +2 more sources