Results 171 to 180 of about 171,834 (303)

E3 Ubiquitin-Protein Ligase DTX1 [PDF]

, 2020
openaire   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Unraveling the role of Cullin3 of E3 ubiquitin ligase in salt stress tolerance via proteomics. [PDF]

BMC Plant Biol
Herwibawa B, Lekklar C, Roytrakul S, Ito T, Chadchawan S, Buaboocha T.   +5 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The Putative E3 Ubiquitin Ligase TEX1 Is Required for Nuclear Biology and Developmental Progression of Plasmodium berghei in the Liver. [PDF]

Cells
Schmid M, Golomingi R, Franke-Fayard B, Caldelari R, Rehmann R, Roques M, Heussler VT.   +6 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase. [PDF]

PLoS Pathog
Liu S, He C, Zhang Y, Liu S, Chen TT, Li C, Chen D, Ouyang S, Song L, Fu J, Luo ZQ.   +10 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase TRAF7 [PDF]

, 2020
openaire   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Identification and characterization of U-box E3 ubiquitin ligase genes (ChPUBs) in Cardamine hupingshanensis under abiotic stress. [PDF]

BMC Genomics
Wang Y, Yang F, Wan X, Yu Y, Tang L, Xie J, Xue H, Li Y, Xiang Z, Chen S, Tang Q, Hou Z, Zhou Y, Lu Y.   +13 more
europepmc   +1 more source