Results 301 to 310 of about 176,319 (351)

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. [PDF]

Nat Commun
Ahel J, Balci A, Faas V, Grabarczyk DB, Harmo R, Squair DR, Zhang J, Roitinger E, Lamoliatte F, Mathur S, Deszcz L, Bell LE, Lehner A, Williams TL, Sowar H, Meinhart A, Wood NT, Clausen T, Virdee S, Fletcher AJ.   +19 more
europepmc   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

The E3 ubiquitin ligase adaptor KLHL8 targets ZAR1 to regulate maternal mRNA degradation in oocytes. [PDF]

EMBO Rep
Fan H, Liu R, Yu R, Chen B, Li Q, Mu J, Wang W, Wu T, He L, Wang L, Sang Q, Zhang Z.   +11 more
europepmc   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Abnormal Fetuin-A levels in obese horses are associated with activated TLR4/NF-ƙB/MAPK axis and depleted FBXW7 E3 ubiquitin ligase. [PDF]

Vet Res Commun
Bourebaba L, Panek M, Piedra LCC, Bourebaba N.   +3 more
europepmc   +1 more source

The <i>Arabidopsis</i> E3 ubiquitin ligase PUB13 synergistically interacts with BON1 to regulate plant flowering and immunity. [PDF]

Front Plant Sci
Yue J, Zou X, Peng Y, Pan S, Hu C, Wang B, Dai L, Li W.   +7 more
europepmc   +1 more source

An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina. [PDF]

PLoS Pathog
Wang H, Zhang J, Liu R, Li Y, Du Y, Wei T.   +5 more
europepmc   +1 more source

The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth. [PDF]

Neural Regen Res
Cai Z, Wu H, Jiang T, Ma A, Meng Z, Zhu J, Lin H, Liang Y, Zhang G, Tan M.   +9 more
europepmc   +1 more source

The RNA helicase DDX17 enhances androgen receptor stability by interacting with the E3 ubiquitin ligase SPOP in prostate cancer. [PDF]

Transl Androl Urol
Maheremu M, Zheng B, Wen H, Wei Q, Lv S.
europepmc   +1 more source

Corrigendum to "E3 ubiquitin ligase RNF128 attenuates colitis and colorectal tumorigenesis by triggering the degradation of IL-6 receptors" [J. Adv. Res. 72 (2025) 107-120]. [PDF]

J Adv Res
He TS, Cai K, Lai W, Yu J, Qing F, Shen A, Sui L, He W, Wang W, Xiao Q, Lei X, Guo T, Liu Z.   +12 more
europepmc   +1 more source