Results 1 to 10 of about 230,401 (303)

Structural Diversity of Ubiquitin E3 Ligase

Molecules, 2021
The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Shimizu Toshiyuki
exaly   +3 more sources

Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex [PDF]

Nature Communications
Ubiquitin modifications regulate fundamental cellular activities by modulating protein stability and function. The ubiquitin ligase COP1, which is present across species from plants to humans, plays a crucial role in the ubiquitination of developmental ...
Shan Wang, Fei Teng, Goran Stjepanovic, Feng Rao, Ming-Yuan Su   +4 more
doaj   +2 more sources

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

Pathology and Oncology Research, 2023
Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis ...
Aiqin Sun, Aiqin Sun, Xianyan Tian, Yifei Chen, Wannian Yang, Qiong Lin   +5 more
doaj   +1 more source

Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome

Life Science Alliance, 2022
The authors use photocrosslinking activity-based probes to monitor RNF12/RLIM E3 ubiquitin ligase activity and report the impact of Tonne-Kalscheuer syndrome (TOKAS) patient variants on catalysis.
Francisco Bustos, Sunil Mathur, Carmen Espejo-Serrano, Rachel Toth, C James Hastie, Satpal Virdee, Greg M Findlay   +6 more
doaj   +1 more source

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites

Biomolecules, 2021
Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome ...
Rebeca Ibarra, Heather R. Borror, Bryce Hart, Richard G. Gardner, Gary Kleiger   +4 more
doaj   +1 more source

Ubiquitin ligase activity inhibits Cdk5 to control axon termination.

PLoS Genetics, 2022
The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion.
Muriel Desbois, Karla J Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill   +5 more
doaj   +1 more source

The EHEC type III effector NleL is an E3 ubiquitin ligase that modulates pedestal formation. [PDF]

PLoS ONE, 2011
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic colitis and may result in potentially fatal hemolytic uremia syndrome in humans. EHEC colonize the intestinal mucosa and promote the formation of actin-rich pedestals via translocated ...
Heather Piscatelli, Shalaka A Kotkar, Megan E McBee, Sureshkumar Muthupalani, David B Schauer, Robert E Mandrell, John M Leong, Daoguo Zhou   +7 more
doaj   +1 more source

Genome-Wide Identification of the U-Box E3 Ubiquitin Ligase Gene Family in Cabbage (Brassica oleracea var. capitata) and Its Expression Analysis in Response to Cold Stress and Pathogen Infection

Plants, 2023
Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses in many species. However, the characteristics of U-box E3 ubiquitin ligase genes in cabbage (Brassica oleracea var.
Peiwen Wang, Lin Zhu, Ziheng Li, Mozhen Cheng, Xiuling Chen, Aoxue Wang, Chao Wang, Xiaoxuan Zhang   +7 more
doaj   +1 more source

Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase

Cells, 2022
Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6 complex contains a variant RING domain carried by its Nse1 subunit.
Peter Kolesar, Karel Stejskal, David Potesil, Johanne M. Murray, Jan J. Palecek   +4 more
doaj   +1 more source

G3BP1 modulates SPOP to promote prostate tumorigenesis

Molecular & Cellular Oncology, 2022
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However,
Chandrani Mukhopadhyay, Pengbo Zhou
doaj   +1 more source