Computational identification of ubiquitylation sites from protein sequences [PDF]
BMC Bioinformatics, 2008 Background Ubiquitylation plays an important role in regulating protein functions. Recently, experimental methods were developed toward effective identification of ubiquitylation sites.
Ho Shinn-Ying, Tung Chun-Wei
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Remodeling Membrane Binding by Mono-Ubiquitylation
Biomolecules, 2019 Ubiquitin (Ub) receptors respond to ubiquitylation signals. They bind ubiquitylated substrates and exert their activity in situ. Intriguingly, Ub receptors themselves undergo rapid ubiquitylation and deubiquitylation.
Neta Tanner +3 more
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Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS) [PDF]
Communications BiologyThe ubiquitin system regulates virtually all cellular processes, yet the vast majority of ubiquitylation sites identified in the human proteome cannot be attributed to specific E3 ligases.
Tanner M. Tessier +9 more
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Non-proteolytic ubiquitylation in cellular signaling and human disease
Communications Biology, 2022 International audienceAbstract Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation.
Izabela Sumara +2 more
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Nature Cell Biology, 2012 Protein ubiquitylation has emerged as a key regulatory mechanism in DNA-damage signalling and repair pathways. We report a proteome-wide, site-specific survey of ubiquitylation changes after ultraviolet irradiation, identifying numerous upregulated and ...
Petra Beli +2 more
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The role of the nucleus in the control of mitochondrial precursor proteins in yeast. [PDF]
Protein SciAbstract Mitochondria are essential organelles of eukaryotic cells, with vital roles in energy production, biosynthesis of macromolecules, and intracellular signaling. Their function depends on a complex proteome with proteins targeted to different mitochondrial sub‐compartments.
Ritzenhofen K +3 more
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Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes [PDF]
Frontiers in Molecular BiosciencesSepsis is a life-threatening disease with high mortality and one of the leading causes of death worldwide. Although studies have shown that ubiquitylation is closely related to the occurrence and development of sepsis, the prognostic and diagnostic value
Haiyan Xue +4 more
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Aging and diet alter the protein ubiquitylation landscape in the mouse brain
Nature CommunicationsPost-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs remains unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in the mouse
Antonio Marino +7 more
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CellUbiquitylation regulates most proteins and biological processes in a eukaryotic cell. However, the site-specific occupancy (stoichiometry) and turnover rate of ubiquitylation have not been quantified.
Shankha Satpathy +2 more
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Biotinylation Interferes with Protein Ubiquitylation and Turnover in Arabidopsis-A Cautionary Insight for Proximity Labeling in Ubiquitylation Proteome Studies. [PDF]
Int J Mol SciNearly all eukaryotic proteins are turned over by the ubiquitin (Ub)-26S proteasome system (UPS). Despite its broad cellular roles, only a handful of UPS members, particularly the Ub E3 ligases that specifically recognize a protein for ubiquitylation ...
Li Y, Yu P, Hua Z.
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