Results 21 to 30 of about 29,730 (229)
Ubiquitylation and cell signaling [PDF]
The EMBO Journal, 2005 Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly-Ub (lysine 63) chains to proteins control gene transcription, DNA repair and replication, intracellular trafficking and virus budding.
Kaisa, Haglund, Ivan, Dikic
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MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4 [PDF]
, 2015 Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy.
Susan E. Bray (264528) +41 more
core +2 more sources
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Simone Fulda +5 more
core +1 more source
Ubiquitylation and the pathogenesis of hypertension [PDF]
Journal of Clinical Investigation, 2013 Liddle syndrome is monogenic hypertension caused by mutations in the epithelial Na+ channel (ENaC) that interfere with its ubiquitylation by Nedd4-2. In this issue, Ronzaud and colleagues found that deleting Nedd4-2 from kidney tubules in adult mice led to ENaC accumulation, but not at the plasma membrane, as predicted from current models.
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Oncoprotein ubiquitylation [PDF]
Cell Cycle, 2014 Many molecular events are terminated by rapid protein degradation via the ubiquitin–proteasome system. Most target proteins are recognized by E3 ubiquitin ligases, often after specific protein modifications, leading to their poly-ubiquitylation and subsequent degradation by the proteasome.
Welcker, Markus, Clurman, Bruce E
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BRCA1-Mediated Ubiquitylation [PDF]
Cell Cycle, 2006 The BRCA1 tumour suppressor and its heterodimeric partner BARD1 play crucial roles in coordinating cellular responses to DNA damage. Evidence also implicates these proteins in transcriptional regulation, cell cycle progression and meiotic sex chromosome inactivation, but their mode of action remains elusive.
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Dynamic regulation of PCNA ubiquitylation/deubiquitylation [PDF]
, 2011 Proliferating Cell Nuclear Antigen (PCNA) ubiquitylation plays a crucial role in maintaining genomic stability during DNA replication. DNA damage stalling the DNA replication fork induces PCNA ubiquitylation that activates DNA damage bypass to prevent ...
Kyoo-young Lee +5 more
core +1 more source
Ubiquitylation Directly Induces Fold Destabilization of Proteins [PDF]
, 2016 Ubiquitin is a common post-Translational modifier and its conjugation is a key signal for proteolysis by the proteasome. Because the molecular mass of ubiquitin is larger than that of other modifiers such as phosphate, acetyl, or methyl groups ...
Morimoto, Daichi +4 more
core +1 more source
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer
Clinical and Translational Medicine, 2022 Background Cyclin C (CCNC) was reported to take part in regulating mitochondria‐derived oxidative stress under cisplatin stimulation. However, its effect in gastric cancer is unknown.
Hong‐yue Jiang +7 more
doaj +1 more source
Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor
Lupus Science and Medicine, 2021 Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen +5 more
doaj +1 more source