Results 21 to 30 of about 28,143 (190)
Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor
Lupus Science and Medicine, 2021 Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen +5 more
doaj +1 more source
Ubiquitylation Directly Induces Fold Destabilization of Proteins [PDF]
, 2016 Ubiquitin is a common post-Translational modifier and its conjugation is a key signal for proteolysis by the proteasome. Because the molecular mass of ubiquitin is larger than that of other modifiers such as phosphate, acetyl, or methyl groups ...
Morimoto, Daichi +4 more
core +1 more source
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
eLife, 2019 Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen +11 more
doaj +1 more source
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer
Clinical and Translational Medicine, 2022 Background Cyclin C (CCNC) was reported to take part in regulating mitochondria‐derived oxidative stress under cisplatin stimulation. However, its effect in gastric cancer is unknown.
Hong‐yue Jiang +7 more
doaj +1 more source
USP45 and Spindly are part of the same complex implicated in cell migration
Scientific Reports, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Claudia Conte +3 more
doaj +1 more source
Protein Ubiquitylation in Pancreatic Cancer [PDF]
, 2010 Pancreatic cancer is one of the worst, as almost 100% of patients will die within 5 years after diagnosis. The tumors are characterized by an early, invasive, and metastatic phenotype, and extreme resistance to all known anticancer therapies.
Thomas Bonacci +2 more
core +1 more source
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +1 more source
Decoding histone ubiquitylation
Frontiers in Cell and Developmental Biology, 2022 Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling.
Jennifer J. Chen +2 more
doaj +1 more source
Nature Communications, 2023 Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation.
Camilla S. Colding-Christensen +9 more
doaj +1 more source
Neddylation is essential for β-catenin degradation in Wnt signaling pathway
Cell Reports, 2022 Summary: β-Catenin is a central component in the Wnt signaling pathway; its degradation has been tightly connected to ubiquitylation, but it is rarely examined by loss-of-function assays.
Bojun Wang +9 more
doaj +1 more source