Results 31 to 40 of about 29,730 (229)
An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins
Bio-Protocol, 2017 We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) (Fulcher et al., 2016 and 2017).
Thomas Macartney +2 more
doaj +1 more source
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function [PDF]
, 2010 The ubiquitously expressed mammalian Na(+)/H(+) exchanger 1 (NHE1) controls cell volume and pH but is also critically involved in complex biological processes like cell adhesion, cell migration, cell proliferation, and mechanosensation.
Alexandre Simonin +3 more
core +1 more source
USP45 and Spindly are part of the same complex implicated in cell migration
Scientific Reports, 2018 Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Claudia Conte +3 more
doaj +1 more source
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
eLife, 2019 Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen +11 more
doaj +1 more source
Ubiquitylation of DNA polymerase λ
FEBS Letters, 2011 DNA polymerase (pol) λ, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino‐acid protein containing a polymerase, a dRP‐lyase, a proline/serine rich and a BRCT domain. Pol λ shows various enzymatic activities including DNA polymerization, terminal transferase and dRP‐lyase.
Markkanen Enni +3 more
openaire +4 more sources
Regulation of the Cardiac Iks Channel Complex by Ubiquitylation and De-Ubiquitylation [PDF]
Biophysical Journal, 2010 KCNQ1 and its β-subunit KCNE1 form the delayed rectifier potassium current IKs, playing an important role in repolarisation of the cardiac tissue and in water and salt transport across epithelial tissues. In the heart IKs is partly responsible for terminating the cardiac action potential.
Krzystanek, Katarzyna +4 more
openaire +1 more source
Ubiquitylation of voltage-gated sodium channels.
, 2014 Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation.
Cédric J. Laedermann +8 more
core +1 more source
Regulation of Unperturbed DNA Replication by Ubiquitylation [PDF]
, 2015 Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation
Gambus, Agnieszka; id_orcid +3 more
core +1 more source
Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP
Bio-Protocol, 2016 VPS34 is the only class III phosphatidylinositol-3-kinase (PI3K) in mammalian cells and produces the vast majority of cellular phosphatidylinositol-3-phosphate [PI(3)P].
Michael Munson, Ian Ganley
doaj +1 more source
Nature Communications, 2023 Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation.
Camilla S. Colding-Christensen +9 more
doaj +1 more source