Results 51 to 60 of about 29,730 (229)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components [PDF]

, 2023
In terms of its relative frequency, lysine is a common amino acid in the human proteome. However, by bioinformatics we find hundreds of proteins that contain long and evolutionarily conserved stretches completely devoid of lysine residues.
Oelerich, Nicole, Nicole Oelerich, Kresten Lindorff-Larsen, Caroline Kampmeyer, Michael H. Tatham, Hofmann, Kay, Cagiada, Matteo, Wouter Boomsma, Rasmus Hartmann-Petersen, Tatham, Michael H., Kampmeyer, Caroline, Lindorff-Larsen, Kresten, Boomsma, Wouter, Matteo Cagiada, Martin Grønbæk-Thygesen, Grønbæk-Thygesen, Martin, Kay Hofmann, Hartmann-Petersen, Rasmus   +17 more
core   +1 more source

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Scientific Reports
Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not.
Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, Giulia Saredi, Rachel Toth, John Rouse   +7 more
doaj   +1 more source

PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.

PLoS Genetics, 2017
PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established.
Yasukazu Daigaku, Thomas J Etheridge, Yuka Nakazawa, Mayumi Nakayama, Adam T Watson, Izumi Miyabe, Tomoo Ogi, Mark A Osborne, Antony M Carr   +8 more
doaj   +1 more source

MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation

Life Science Alliance, 2022
MMD-associated SNPs of RNF213 encode dominant-negative alleles that globally impair ubiquitylation by RNF213-UBE2D2. Single-nucleotide polymorphisms (SNPs) in RNF213 , which encodes a 591-kD protein with AAA+ ATPase and RING E3 domains, are associated ...
Abhishek Bhardwaj, Robert S Banh, Wei Zhang, Sachdev S Sidhu, Benjamin G Neel   +4 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Studying Protein Ubiquitylation in Yeast [PDF]

, 2016
Ubiquitylation is a reversible posttranslational modification that is critical for most, if not all, cellular processes and essential for viability. Ubiquitin conjugates to substrate proteins either as a single moiety (monoubiquitylation) or as polymers composed of ubiquitin molecules linked to each other with various topologies and structures ...
Hovsepian, Junie, Becuwe, Michel, Kleifeld, Oded, Glickman, Michael, Léon, Sébastien   +4 more
openaire   +3 more sources

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

eLife, 2017
DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous ...
Martijn S Luijsterburg, Dimitris Typas, Marie-Christine Caron, Wouter W Wiegant, Diana van den Heuvel, Rick A Boonen, Anthony M Couturier, Leon H Mullenders, Jean-Yves Masson, Haico van Attikum   +9 more
doaj   +1 more source

A representation and deep learning model for annotating ubiquitylation sentences stating E3 ligase - substrate interaction

BMC Bioinformatics, 2021
Background Ubiquitylation is an important post-translational modification of proteins that not only plays a central role in cellular coding, but is also closely associated with the development of a variety of diseases. The specific selection of substrate
Mengqi Luo, Zhongyan Li, Shangfu Li, Tzong-Yi Lee   +3 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source