Results 11 to 20 of about 29,730 (229)
Ubiquitylation of Ion Channels
Physiology, 2005 Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several ...
Olivier Staub +3 more
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Decoding histone ubiquitylation
Frontiers in Cell and Developmental Biology, 2022 Histone ubiquitylation is a critical part of both active and repressed transcriptional states, and lies at the heart of DNA damage repair signaling.
Jennifer J. Chen +2 more
doaj +3 more sources
Computational identification of ubiquitylation sites from protein sequences [PDF]
BMC Bioinformatics, 2008 Background Ubiquitylation plays an important role in regulating protein functions. Recently, experimental methods were developed toward effective identification of ubiquitylation sites.
Ho Shinn-Ying, Tung Chun-Wei
doaj +2 more sources
Protein Ubiquitylation in Pancreatic Cancer [PDF]
The Scientific World JOURNAL, 2010 Pancreatic cancer is one of the worst, as almost 100% of patients will die within 5 years after diagnosis. The tumors are characterized by an early, invasive, and metastatic phenotype, and extreme resistance to all known anticancer therapies.
Thomas Bonacci +2 more
core +5 more sources
Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Nature Cell Biology, 2008 International audienceMono-ubiquitylation of histone H2B correlates with transcriptional activation and is required for di- and trimethylation at Lys 4 on the histone H3 tail (H3K4) by the SET1/COMPASS methyltransferase complex through a poorly ...
Menant, Alexandra +5 more
core +4 more sources
Reversible ubiquitylation in plant biology [PDF]
Frontiers in Plant Science, 2014 Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system ...
Pascal eGENSCHIK +6 more
core +7 more sources
Another facet of ubiquitylation: death [PDF]
Journal of Molecular Cell Biology, 2009 Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequesto- some-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell ...
Silke, John, Wong, W Wei-Lynn
core +3 more sources
UbiProt: a database of ubiquitylated proteins [PDF]
BMC Bioinformatics, 2007 Background Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases.
Kondratieva Ekaterina V +5 more
doaj +3 more sources
Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis-Mediated Lung Injury. [PDF]
Exploration (Beijing)Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Chang J +9 more
europepmc +2 more sources
IUBMB Life, 2012 AbstractThe Inhibitor of apoptosis (IAP) proteins are key negative regulators of cell death, whose amplification has been correlated with tumor progression. Due to the presence of a RING domain, IAP proteins are classed as ubiquitin ligases and regulate cell survival by orchestrating a variety of ubiquitin modifications.
Rebecca, Feltham +2 more
openaire +2 more sources