Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment [PDF]
Frontiers in ImmunologyUbiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life.
Kun Zhang, Hui Yuan, Lin Shi
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The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer [PDF]
Cell Death Discovery, 2023 To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen +8 more
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A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases [PDF]
BiomoleculesUbiquitination is one of the most important post-translational modifications in eukaryotes. The ubiquitination cascade includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The E3 ligases, responsible
Zuo-Xian Pu +9 more
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E3 ubiquitin ligases: key regulators of osteogenesis and potential therapeutic targets for bone disorders [PDF]
Frontiers in Cell and Developmental BiologyUbiquitination is a crucial post-translational modification of proteins that mediates the degradation or functional regulation of specific proteins. This process participates in various biological processes such as cell growth, development, and signal ...
Heng-Rui Zhang +10 more
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Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone [PDF]
BiomoleculesE3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He +3 more
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Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies [PDF]
Frontiers in Cell and Developmental BiologyMultiple myeloma (MM) is a hematological tumor characterized by the malignant proliferation of plasma cells in bone marrow (BM). Despite the prolonged survival of MM patients, a significant amount of patients relapse or become drug resistant.
Xiaoran Chen +7 more
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Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases [PDF]
Experimental and Molecular Medicine, 2023 Posttranslational modification of proteins via ubiquitination determines their activation, translocation, dysregulation, or degradation. This process targets a large number of cellular proteins, affecting all biological pathways involved in the cell ...
Yelin Jeong +5 more
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E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review
Journal of Pharmacy and Bioallied SciencesE3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction.
Azfar Jamal
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The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy
Frontiers in Immunology, 2023 Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang +4 more
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Structural Diversity of Ubiquitin E3 Ligase [PDF]
Molecules, 2021 The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes. Three enzymes are required for achieving the ubiquitination reaction: ubiquitin-activating enzyme (E1),
Toma-Fukai, Sachiko, Shimizu, Toshiyuki
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