Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment [PDF]
Frontiers in ImmunologyUbiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life.
Kun Zhang, Hui Yuan, Lin Shi
doaj +2 more sources
The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer [PDF]
Cell Death Discovery, 2023 To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen +8 more
doaj +2 more sources
E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies [PDF]
Frontiers in Molecular BiosciencesThe Ubiquitin-Proteasome System (UPS) is a key mechanism of cellular homeostasis. A central part of this mechanism is E3 ubiquitin ligases, which selectively direct proteins to be ubiquitinated for degradation via the UPS.
Srineevas Sriram +2 more
doaj +2 more sources
A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases [PDF]
BiomoleculesUbiquitination is one of the most important post-translational modifications in eukaryotes. The ubiquitination cascade includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The E3 ligases, responsible
Zuo-Xian Pu +9 more
doaj +2 more sources
E3 ubiquitin ligases: key regulators of osteogenesis and potential therapeutic targets for bone disorders [PDF]
Frontiers in Cell and Developmental BiologyUbiquitination is a crucial post-translational modification of proteins that mediates the degradation or functional regulation of specific proteins. This process participates in various biological processes such as cell growth, development, and signal ...
Heng-Rui Zhang +10 more
doaj +2 more sources
Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone [PDF]
BiomoleculesE3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He +3 more
doaj +2 more sources
Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies [PDF]
Frontiers in Cell and Developmental BiologyMultiple myeloma (MM) is a hematological tumor characterized by the malignant proliferation of plasma cells in bone marrow (BM). Despite the prolonged survival of MM patients, a significant amount of patients relapse or become drug resistant.
Xiaoran Chen +7 more
doaj +2 more sources
Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases [PDF]
Experimental and Molecular Medicine, 2023 Posttranslational modification of proteins via ubiquitination determines their activation, translocation, dysregulation, or degradation. This process targets a large number of cellular proteins, affecting all biological pathways involved in the cell ...
Yelin Jeong +5 more
doaj +2 more sources
E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review
Journal of Pharmacy and Bioallied SciencesE3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction.
Azfar Jamal
doaj +2 more sources
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]
, 2012 Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bajer, Magdalena M. +11 more
core +19 more sources