Results 11 to 20 of about 49,812 (243)

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer [PDF]

Pathology and Oncology Research, 2023
Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis ...
Aiqin Sun, Aiqin Sun, Xianyan Tian, Yifei Chen, Wannian Yang, Qiong Lin   +5 more
doaj   +3 more sources

E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration [PDF]

Frontiers in Molecular Neuroscience, 2017
Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging.
Arun Upadhyay, Vibhuti Joshi, Ayeman Amanullah, Ribhav Mishra, Naina Arora, Amit Prasad, Amit Mishra   +6 more
doaj   +3 more sources

How to Inactivate Human Ubiquitin E3 Ligases by Mutation [PDF]

Frontiers in Cell and Developmental Biology, 2020
E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein.
Cristina Garcia-Barcena, Nerea Osinalde, Juanma Ramirez, Ugo Mayor, Ugo Mayor   +4 more
doaj   +3 more sources

Novel RING E3 Ubiquitin Ligases in Breast Cancer [PDF]

Neoplasia: An International Journal for Oncology Research, 2006
Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways.
Angelika Burger, Yutaka Amemiya, Richard Kitching, Arun K. Seth   +3 more
doaj   +2 more sources

Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies [PDF]

Frontiers in Cell and Developmental Biology
Multiple myeloma (MM) is a hematological tumor characterized by the malignant proliferation of plasma cells in bone marrow (BM). Despite the prolonged survival of MM patients, a significant amount of patients relapse or become drug resistant.
Xiaoran Chen, Jiale Zhou, Xiaoqing Dong, Xiaoqing Dong, Yan Xu, Yan Xu, Bing Chen, Bing Chen   +7 more
doaj   +2 more sources

E3 Ubiquitin Ligases and Their Therapeutic Applications in Cancers: Narrative Review

Journal of Pharmacy and Bioallied Sciences
E3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction.
Azfar Jamal
doaj   +2 more sources

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Frontiers in Immunology, 2023
Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and ...
Xuemei Wang, Ying Zhang, Yao Wu, Hongjing Cheng, Xueju Wang   +4 more
doaj   +1 more source

Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma

Thoracic Cancer, 2022
Background Lung adenocarcinoma (LUAD) is the most common subtype of non‐small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc‐bing domains that catalyze ubiquitin to
Hao Ding, Yuxin Wang, Yuan Cui, Zhike Chen, Yu Li, Jian Yang, Yang Yang, Tengfei Chen, Dian Xia, Chang Li, Chun Xu, Cheng Ding, Jun Zhao   +12 more
doaj   +1 more source

Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Frontiers in Immunology, 2021
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
Haoran Cui, Haoran Cui, Haoran Cui, Yaxian Zhang, Yaxian Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source

TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions

Computational and Structural Biotechnology Journal, 2023
Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li   +7 more
doaj   +1 more source