Results 51 to 60 of about 149,506 (292)

Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity

Cells, 2021
Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite
Utsa Bhaduri, Giuseppe Merla
doaj   +1 more source

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
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Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]

, 2014
E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M, Carles Galdeano (1305135), Galdeano, Carles, Dias, David M., David M. Dias (1340694), Van Molle, Inge, Gadd, Morgan Stuart, Ciulli, Alessio, Sarah Hewitt (1340700), Soares, Pedro, Galdeano , Carles, Pedro Soares (393566), Gadd, Morgan S., Salvatore Scaffidi (1340703), Inge Van Molle (1284120), Morgan S. Gadd (149371), Scaffidi, Salvatore, Ipek Birced (1340697), Alessio Ciulli (762789), Hewitt, Sarah, Birced, Ipek   +20 more
core   +1 more source

The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer

Cell Death Discovery, 2023
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve the outcome of CRC patients.
Jie Chen, Haimei Feng, Yiting Wang, Xiaoming Bai, Siqi Sheng, Huiyu Li, Mengxi Huang, Xiaoyuan Chu, Zengjie Lei   +8 more
doaj   +1 more source

A capsid-encoded PPxY-motif facilitates adenovirus entry. [PDF]

, 2010
Viruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of nonenveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed after cell surface attachment and ...
Segura-Morales, Carolina, Ruzsics, Zsolt, Kremer, Eric J, Wiethoff, Christopher M, Kremer Eric J., Baptist Jammart, Wodrich, Harald, Jammart, Baptist, Seelmeir Sigrid, Jammart Baptist, Christopher M Wiethoff, Wiethoff, Christopher M., Ruzsics Zsolt, Segura-Morales Carolina, Seelmeir, Sigrid, Carolina Segura-Morales, Henaff, Daniel, Zsolt Ruzsics, Kremer, Eric J., Coux, Olivier, Harald Wodrich, Henaff Daniel, Sigrid Seelmeir, Coux Olivier, Wodrich Harald, Eric J Kremer, Daniel Henaff, Olivier Coux, Wiethoff Christopher M.   +28 more
core   +1 more source

Generation and physiological roles of linear ubiquitin chains [PDF]

, 2012
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
Iwai Kazuhiro, Walczak, H, Walczak, Henning, Kazuhiro Iwai, Walczak Henning, Đikić, Ivan, Ivan Dikic, Iwai, Kazuhiro, Iwai, K, Dikic, I, Dikic Ivan, Henning Walczak   +11 more
core   +1 more source

A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases

Biomolecules
Ubiquitination is one of the most important post-translational modifications in eukaryotes. The ubiquitination cascade includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The E3 ligases, responsible
Zuo-Xian Pu, Jun-Li Wang, Yu-Yang Li, Luo-Yu Liang, Yi-Ting Tan, Ze-Hui Wang, Bao-Lin Li, Guang-Qin Guo, Li Wang, Lei Wu   +9 more
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E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration

Stem Cells International, 2022
The ubiquitination-proteasome system (UPS) is crucial in regulating a variety of cellular processes including proliferation, differentiation, and survival. Ubiquitin protein ligase E3 is the most critical molecule in the UPS system.
Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu   +6 more
doaj   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +2 more sources

Decoding the ubiquitin-mediated pathway of arthropod disease vectors. [PDF]

PLoS ONE, 2013
Protein regulation by ubiquitin has been extensively described in model organisms. However, characterization of the ubiquitin machinery in disease vectors remains mostly unknown.
Anthony Choy, Maiara S Severo, Ruobai Sun, Thomas Girke, Joseph J Gillespie, Joao H F Pedra   +5 more
doaj   +1 more source