Results 71 to 80 of about 149,506 (292)

The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]

, 2015
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Miles, Jennifer A., Carroll, Eilis, Frost, Mark G., Rowe, Michelle L., Walden, Helen   +8 more
core   +1 more source

E3 ubiquitin ligases and abscisic acid signaling [PDF]

Plant Signaling & Behavior, 2011
The ubiquitin proteasome system is involved in the regulation of nearly every aspect of plant growth and development. Protein ubiquitination involves the covalent attachment of ubiquitin to target proteins through a cascade catalyzed by three enzymes known as E1, E2 and E3.
Hongxia, Liu, Sophia L, Stone
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genome-Wide Identification and Expression of Xenopus F-Box Family of Proteins. [PDF]

PLoS ONE, 2015
Protein degradation via the multistep ubiquitin/26S proteasome pathway is a rapid way to alter the protein profile and drive cell processes and developmental changes.
Banu Saritas-Yildirim, Hannah A Pliner, Angelica Ochoa, Elena M Silva   +3 more
doaj   +1 more source

A Tobacco Homolog of DCN1 is Involved in Cellular Reprogramming and in Developmental Transitions [PDF]

, 2011
Plant proteomes show remarkable plasticity in reaction to environmental challenges and during developmental transitions. Some of this adaptability comes from ubiquitin-mediated protein destruction regulated by cullin-RING E3 ubiquitin ligases (CRLs ...
Alexandra Ribarits, Klaus Palme, Marina Baumann, Elisabeth Ankele, Katarzyna Szaszka, Viktor Voronin, Christina Friedmann, Julia Hosp, Alisher Touraev, Yongfeng Jin, Alisher Tashpulatov, Erwin Heberle-Bors, Tatiana Resch   +12 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Image_1_How to Inactivate Human Ubiquitin E3 Ligases by Mutation.jpg

, 2020
E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein.
Ugo Mayor (404331), Cristina Garcia-Barcena (8395278), Nerea Osinalde (2989329), Juanma Ramirez (812674)   +3 more
core   +1 more source

The Role of E3 Ubiquitin Ligases in Chloroplast Function [PDF]

, 2022
Chloroplasts are ancient organelles responsible for photosynthesis and various biosynthetic functions essential to most life on Earth. Many of these functions require tightly controlled regulatory processes to maintain homeostasis at the protein level ...
Hand, Katherine A,; Shabek, Nitzan,, Hand, Katherine A., Nitzan Shabek, Shabek, Nitzan, Katherine A. Hand, Hand, Katherine A   +5 more
core   +1 more source

SCF E3 Ubiquitin Ligases as Anticancer Targets [PDF]

Current Cancer Drug Targets, 2011
The SCF multisubunit complex (Skp1, Cullins, F-box proteins) E3 ubiquitin ligase, also known as CRL (Cullin-RING ubiquitin Ligase) is the largest E3 ubiquitin ligase family that promotes the ubiquitination of various regulatory proteins for targeted degradation, thus regulating many biological processes, including cell cycle progression, signal ...
L, Jia, Y, Sun
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source