Results 81 to 90 of about 68,518 (300)

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source

Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly [version 1; peer review: 2 approved]

F1000Research, 2020
Protein ubiquitylation is essential for the maintenance of cellular homeostasis. E3 ubiquitin ligases are key components of the enzymatic machinery catalyzing the attachment of ubiquitin to substrate proteins. Consequently, enzymatic dysfunction has been
Vishnu Balaji, Thorsten Hoppe
doaj   +1 more source

CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes. [PDF]

PLoS ONE, 2018
RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to ...
Domingo Jiménez-López, Laura Aguilar-Henonin, Juan Manuel González-Prieto, Victor Aguilar-Hernández, Plinio Guzmán   +4 more
doaj   +1 more source

Parkin function in Parkinson's disease [PDF]

, 2018
Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by involuntary shaking, muscle rigidity, and the progressive loss of dopaminergic neurons.
Arkinson, Connor, Walden, Helen
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems [PDF]

, 2007
Our previous work identified E3 ubiquitin ligases, termed UBR1-UBR7, that contain the ~70-residue UBR box, a motif important for the targeting of N-end rule substrates.
Hellweg, Rainer, Hörtnagl, Heidi, Kwon, Yong Tae, Sohr, Reinhard, Tasaki, Takafumi, Varshavsky, Alexander, Xia, Zanxian   +6 more
core   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Novel RING E3 Ubiquitin Ligases in Breast Cancer

Neoplasia: An International Journal for Oncology Research, 2006
Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways.
Angelika Burger, Yutaka Amemiya, Richard Kitching, Arun K. Seth   +3 more
doaj   +1 more source

Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis [PDF]

, 2017
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins ...
Amerik, Anckar, Apaja, Arndt, Arndt, Aviram, Balch, Ballinger, Bar-Lavan, Barrott, Bartel, Bays, Becuwe, Behrends, Bengtson, Boban, Boban, Bodnar, Boomsma, Bordallo, Brandman, Brehme, Broersen, Buchner, Calderwood, Carra, Catlett, Choe, Christianson, Chu, Ciechanover, Ciocca, Ciryam, Commerford, Connell, Craig, Crippa, Crosas, Cuervo, Cuervo, Cyr, Dai, Davies, Defenouillere, Deng, Deyter, Donati, Douglas, Douglas, Dunker, Duttler, Ehrlich, Eisele, Ellis, Fan, Fang, Fang, Fang, Fang, Ferreira, Finley, Finley, Foresti, Fourie, Fredrickson, Gallagher, Gamerdinger, Gardner, Garrido, Goldberg, Guerriero, Guo, Han, Hartl, Hatakeyama, Heck, Hemmingsen, Hessa, Hettema, Higy, Hondele, Hondele, Hoppe, Iwata, Jana, Jego, Jiang, Jin, Joshi, Kahn, Kampinga, Kaplan, Katsogiannou, Kaushik, Kaushik, Keller, Kenyon, Kerscher, Kettern, Khmelinskii, Kim, Kitagawa, Koegl, Komander, Koren, Kraft, Kuhlbrodt, Kuhlbrodt, Kumar, Kuo, Kwon, Laba, Labbadia, Lakshmipathy, Lee, Lerch-Bader, Levine, Li, Li, Lopez, Lopez-Otin, MacGurn, Maier, Matsumura, Mattiroli, Maurer, McDonough, Meacham, Mehnert, Meng, Merz, Metzger, Min, Mishra, Mizushima, Morano, Morimoto, Morimoto, Morimoto, Morishima, Murata, Murata, Nahleh, Nillegoda, Nillegoda, Nillegoda, Park, Park, Paul, Petrucelli, Powers, Powers, Prasad, Qian, Ranford, Rape, Ravid, Rees, Roberts, Roberts, Rodina, Rodrigo-Brenni, Rosenbaum, Ruggiano, Russell, Rüb, Rüdiger, Saez, Saibil, Salminen, Samant, Schopf, Shahsavarani, Shao, Shiber, Shiga, Shin, Singh, Singh, Singh, Soss, Sowa, Spiechowicz, Stuttmann, Sulistio, Sultana, Summers, Sung, Swanson, Taipale, Takayama, Tasaki, Tasaki, Tawo, Taylor, Terman, Tzankov, Ulbricht, Urushitani, VanPelt, Venkatesh, Verma, Vilchez, Walther Dirk, Wang, Wang, Willhoft, Williams, Xie, Xu, Xu, Yonashiro, Yu, Zargari, Zhang, Zhang, Zhao, Zhao, Zhou, Zuehlke, Zuiderweg   +220 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source