Results 111 to 120 of about 327,500 (191)

Multifunction Steroid Receptor Coactivator, E6-Associated Protein, Is Involved in Development of the Prostate Gland

, 2005
In this study we report that deletion of E6-associated protein (E6-AP) in mice results in a smaller prostate gland compared with that in normal wild-type animals.
Shan Lu, Cao, Xuni, Lu, Shan, Xuni Cao, Zafar Nawaz, Yaping Tu, Tu, Yaping, Sathish Srinivasan, Ismail, Ayesha, Obaid Y. Khan, Ayesha Ismail, Khan, Obaid Y, Fu, Guilian, Srinivasan, Sathish, Nawaz, Zafar, Guilian Fu   +15 more
core   +1 more source

Abstract 3204: The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase

, 2010
Cervical cancer is the second most common cancer among women worldwide. A necessary factor in the development of nearly all cases of cervical cancer is the human papillomavirus (HPV) infection.
Dan A. Dixon, Vimala Kaza, Sandhya Sanduja   +2 more
core   +1 more source

Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex [PDF]

, 2018
<p>Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation ...
Scheffner, M, Walker-Gray, R, Julier, Alexandra, Kammer, K-M, Gold, Matthew G. (5644385), Walker-Gray,Ryan (5633216), Sailer,Carolin, Scheffner,Martin (5633222), Kammer,Kai-Michael, Walker-Gray,Ryan, Stengel, Florian (5644391), Julier,Alexandra (5633210), Scheffner,Martin, Kammer, Kai-Michael (5644379), Kammer,Kai-Michael (5633213), Julier, A, Offensperger,Fabian, Walker-Gray, Ryan, Scheffner, Martin, Gold, Matthew G., Julier, Alexandra (5644376), Offensperger, Fabian, Julier,Alexandra, Gold, MG, Walker-Gray, Ryan (5644382), Offensperger, Fabian (5644373), Stengel,Florian (5633225), Sailer, C, Kammer, Kai-Michael, Stengel,Florian, Gold,Matthew G., Sailer, Carolin, Sailer,Carolin (5633204), Stengel, F, Offensperger, F, Sailer, Carolin (5644370), Offensperger,Fabian (5633207), Stengel, Florian, Scheffner, Martin (5644388), Gold,Matthew G. (5633219)   +39 more
core   +1 more source

CARACTERIZACIÓN DE ÁCIDOS HÚMICOS Y FÚLVICOS DE UN MOLLISOL BAJO DOS COBERTURAS DIFERENTES

Revista Colombiana de Química, 2008
Para evaluar y comparar algunas propiedades de los ácidos húmicos (AH) y fúlvicos (AF) como el grado de condensación y polimerización, el contenido total de carbono, hidrógeno y nitrógeno, y sus constantes
Ingris Zamboni, María Inés Ballesteros, Adriana Zamudio   +2 more
doaj  

Angelman syndrome: review of clinical and molecular aspects

The Application of Clinical Genetics, 2014
Lynne M Bird1Department of Pediatrics, University of California, Division of Genetics, Rady Children’s Hospital, San Diego, California, USAAbstract: “Angelman syndrome” (AS) is a neurodevelopmental disorder whose main features are ...
Bird LM
doaj  

Role of E6-AP in Steroid Hormone Receptor-Dependent Transcription and Cellular Function

, 2009
Steroid receptor coactivators modulate the final outcome of hormone induced gene transcription by steroid receptors. E6-associated protein (E6-AP), an E3 ubiquitin ligase, acts as a coactivator of steroid receptors, including estrogen receptor (ER).
Srinivasan, Sathish
core  

The role of HECT-type E3 ubiquitin ligases in inflammation

Frontiers in Immunology
Homologous to the E6-AP Carboxyl Terminus (HECT)-type E3 ubiquitin ligases are key components of the ubiquitin-proteasome system (UPS) and play an important role in the regulation of inflammatory responses. Inflammation serves as a core defense mechanism
Ziyi Wang, Peirui Wang, Huawang Xie, Zhibo You, Xiping Liu, Fang Cao, Shengtao Yao   +6 more
doaj   +1 more source

Are all species necessary to reveal ecologically important patterns?

Ecology and Evolution, 2014
While studying ecological patterns at large scales, ecologists are often unable to identify all collections, forcing them to either omit these unidentified records entirely, without knowing the effect of this, or pursue very costly and time‐consuming ...
Edwin Pos, Juan Ernesto Guevara Andino, Daniel Sabatier, Jean‐François Molino, Nigel Pitman, Hugo Mogollón, David Neill, Carlos Cerón, Gonzalo Rivas, Anthony Di Fiore, Raquel Thomas, Milton Tirado, Kenneth R. Young, Ophelia Wang, Rodrigo Sierra, Roosevelt García‐Villacorta, Roderick Zagt, Walter Palacios, Milton Aulestia, Hans ter Steege   +19 more
doaj   +1 more source

p53 Codon 72 Polymorphism and Risk of Cervical Cancer

Biological Research, 2003
Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of
JOSÉ M OJEDA, SANDRA AMPUERO, PATRICIO ROJAS, RODRIGO PRADO, JORGE E ALLENDE, SARA A BARTON, RANAJIT CHAKRABORTY, FRANCISCO ROTHHAMMER   +7 more
doaj  

Mutational Analysis of Transcriptional Activation by the Bovine Papillomavirus Type 1 E6

, 1997
While the bovine papillomavirus type 1 (BPV-1) E6 induces tumorigenic transformation of murine C127 cells, it does not bind or promote the degradation of p53.
Androphy, Elliot J., Chen, Jason J., Hong, Yihui   +2 more
core   +1 more source