Results 91 to 100 of about 327,500 (191)
E6-AP protein levels were restored to wildtype levels in the TR2-UBE3A treated AS mice.
, 2013 (A) Representative coronal slices through the hippocampus from each group stained for E6-AP. (B) Quantitative analysis of the IHC revealed a significant increase in E6-AP expression in the WT and AS-TR2-UBE3A mice compared to the AS TR2-GFP group, while ...
Todd Golde (337754) +9 more
core +1 more source
Recruitment of AP-1 clathrin adaptors to liposomal membranes [PDF]
, 2004 Protein and membrane traffic between organelles within the endocytic and exocytic pathway is mediated most prominently by coated vesicles. These vesicles are formed by the assembly of cytosolic coat proteins onto the donor membrane, which deform it into ...
Meyer, Daniel Markus
core +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling
BMC Genomics, 2010 Background Functional comparative genomic analysis of the cellular immunological effects of different anti-inflammatory phytocompounds is considered as a helpful approach to distinguish the complex and specific bioactivities of candidate phytomedicines ...
Vanisree Staniforth +5 more
doaj +1 more source
The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer
, 2007 Includes bibliographical references (leaves 74-83).Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males.
Ross-Innes, Caryn Sarah
core
Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53 [PDF]
, 2012 SummaryThe viral oncoprotein E6 is an essential factor for cervical cancers induced by “high-risk” mucosal HPV. Among other oncogenic activities, E6 recruits the ubiquitin ligase E6AP to promote the ubiquitination and subsequent proteasomal degradation ...
Kieffer, B. (Bruno) +16 more
core +1 more source
Higher Education Quarterly, Volume 80, Issue 3, July 2026.ABSTRACT In knowledge‐based societies, withdrawal from doctoral education is often seen and spoken about as embarrassing, undesirable, and awkward. Emerging from complex conditions—a mix of profoundly personal factors and weighty contextual factors—withdrawal tends to be a silenced or shamed process, producing a layered dynamic of taboo upon taboo upon
Patrícia Alves +4 more
wiley +1 more source
Aggregate, Volume 7, Issue 6, June 2026.This work presents a positional isomer engineering strategy to create a microenvironment‐tolerant NIR‐II AIEgen. The para‐isomer exhibits optimized excited‐state dynamics, enabling potent Type‐I photodynamic activity under hypoxia along with photothermal conversion.
Wentian Zhang +12 more
wiley +1 more source
A cytosolic factor mediating membrane recruitment of AP-1 clathrin adaptors [PDF]
, 2008 Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. These vesicles are formed through the recruitment of cytosolic coat proteins to the donor membrane that act as a scaffold to form coated buds and ...
Suri, Gregor
core +1 more source
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +1 more source