Results 71 to 80 of about 327,500 (191)

Characterization of the brain 26S proteasome and its interacting proteins

Frontiers in Molecular Neuroscience, 2010
Proteasome-mediated proteolysis is important for synaptic plasticity, neuronal development, protein quality control, and many other processes in neurons.
Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman, Erin M Schuman   +4 more
doaj   +1 more source

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

Molecular Autism, 2021
Background Angelman Syndrome (AS) is a rare genetic disorder characterized by impaired communication, motor and balance deficits, intellectual disabilities, recurring seizures and abnormal sleep patterns. The genetic cause of AS is neuronal-specific loss
N. A. Copping, J. L. Silverman
doaj   +1 more source

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey

Frontiers in Neuroanatomy
Angelman syndrome (AS) is a neurogenetic disorder caused by mutations or deletions in the maternally-inherited UBE3A allele, leading to a loss of UBE3A protein expression in neurons.
Chavely Gonzalez Ramirez, Chavely Gonzalez Ramirez, Sarah G. Salvador, Sarah G. Salvador, Ridthi Kartik Rekha Patel, Ridthi Kartik Rekha Patel, Sarah Clark, Sarah Clark, Noah W. Miller, Noah W. Miller, Lucas M. James, Lucas M. James, Nicholas W. Ringelberg, Nicholas W. Ringelberg, Jeremy M. Simon, Jeremy M. Simon, Jeffrey Bennett, Jeffrey Bennett, David G. Amaral, David G. Amaral, Alain C. Burette, Alain C. Burette, Benjamin D. Philpot, Benjamin D. Philpot, Benjamin D. Philpot   +24 more
doaj   +1 more source

Multiecho Fat‐Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To introduce a novel multiecho, multishot spiral MR elastography (MRE) sequence to image brain and skull displacement simultaneously using a joint fat‐water image reconstruction and distributed motion encoding. Methods Multiple echo times were implemented into a high‐resolution multishot spiral MRE sequence to capture water‐based brain
Alexa M. Diano, Alex M. Cerjanic, Olivia M. Bailey, Mary K. Kramer, Joy Mojumder, Ruth J. Okamoto, Philip V. Bayly, Dzung L. Pham, Curtis L. Johnson   +8 more
wiley   +1 more source

Angular Insertion Depth for Cochlear Implantation: A Comparative Analysis on Precision of CT, MRI, and x‐Ray

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Personalized medicine in cochlear implantation has advanced significantly with the advent of software tools that allow for detailed analysis of cochlear anatomy. This facilitates the selection of electrode arrays tailored to the individual cochlear duct length (CDL) and supports anatomy‐based fitting strategies. Concurrently, various
Tobias Rader, Hanna Bühler, Matthias P. Fabritius, Martin Canis, Jennifer L. Spiegel   +4 more
wiley   +1 more source

Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans

Journal of Biomedical Science, 2012
Background Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections.
Wagner R, Johnson Shemedia J
doaj   +1 more source

E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy

Frontiers in Physiology, 2020
Ubiquitination is a dynamic post-translational modification that regulates the fate of proteins and therefore modulates a myriad of cellular functions.
Léa Lescouzères, Pascale Bomont
doaj   +1 more source

The E6–AP Ubiquitin–Protein Ligase (UBE3A) Gene Is Localized within a Narrowed Angelman Syndrome Critical Region [PDF]

Genome Research, 1997
Angelman syndrome (AS) and Prader–Willi syndrome (PWS) are distinct clinical phenotypes resulting from maternal and paternal deficiencies, respectively, in human chromosome 15q11–q13. Although several imprinted, paternally expressed transcripts have been identified within the PWS candidate region, no maternally expressed gene has yet been identified ...
J S, Sutcliffe, Y H, Jiang, R J, Galijaard, T, Matsuura, P, Fang, T, Kubota, S L, Christian, J, Bressler, B, Cattanach, D H, Ledbetter, A L, Beaudet   +10 more
openaire   +2 more sources

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source