Results 61 to 70 of about 327,500 (191)

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development

Molecular Brain, 2022
Ubiquitination involves three types of enzymes (E1, E2, and E3) that sequentially attach ubiquitin (Ub) to target proteins. This posttranslational modification controls key cellular processes, such as the degradation, endocytosis, subcellular ...
Alexandre Bouron, Marie-Odile Fauvarque
doaj   +1 more source

The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway [PDF]

, 2008
Non-melanoma skin cancer is the most frequent malignancy in Caucasian populations. Evidence suggests the involvement of cutaneous Human Papillomavirus (HPV) of the genus beta () in this disease. The ability of E6 and E7 of mucosal HPV to promote cellular
Tommasino, M., Gillan, V., Tommasino, Massimo, Gillan, Victoria, Bratlie, S., Bouvard, V., Banks, Lawrence, Banks, L., Campo, M. Saveria, Cordano, Pablo, Cordano, P., Bouvard, Veronique, Campo, M.S., Bratlie, Sigrid   +13 more
core   +1 more source

Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5 [PDF]

Journal of Biological Chemistry, 1996
E6-AP, a 100-kDa cellular protein, was originally identified through its interaction with the E6 protein of the oncogenic human papillomavirus types 16 and 18. The complex of E6-AP and E6 specifically interacts with p53 and mediates ubiquitination of p53 in concert with the E1 ubiquitin-activating enzyme and the E2 ubiquitin-conjugating enzyme UbcH5 ...
U, Nuber, S, Schwarz, P, Kaiser, R, Schneider, M, Scheffner   +4 more
openaire   +2 more sources

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

1031-1034delTAAC (Leu125Stop): a novel familial UBE3A mutation causing Angelman syndrome in two siblings showing distinct phenotypes

BMC Medical Genetics, 2012
Background More than 50 mutations in the UBE3A gene (E6-AP ubiquitin protein ligase gene) have been found in Angelman syndrome patients with no deletion, no uniparental disomy, and no imprinting defect.
De Molfetta Greice Andreotti, Ferreira Cristiane Ayres, Vidal Daniel Onofre, de Rosso Giuliani Liane, Maldonado Maria José, Silva Wilson Araujo   +5 more
doaj   +1 more source

Modeling Non‐GM Segregation Strategies at the Grain Elevator

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objective As new opportunities arise for non‐genetically modified (non‐GM) products in grain markets, segregation becomes crucial but challenging in commodity‐friendly infrastructures such as grain elevators. This study developed probabilistic models using Monte Carlo simulations to evaluate three segregation strategies ...
Priyanka Gupta, Gretchen A. Mosher, Erin L. Bowers, Charles R. Hurburgh   +3 more
wiley   +1 more source

Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. [PDF]

PLoS ONE, 2010
Angelman syndrome (AS) is a neurobehavioral disorder associated with mental retardation, absence of language development, characteristic electroencephalography (EEG) abnormalities and epilepsy, happy disposition, movement or balance disorders, and ...
Yong-Hui Jiang, Yanzhen Pan, Li Zhu, Luis Landa, Jong Yoo, Corinne Spencer, Isabel Lorenzo, Murray Brilliant, Jeffrey Noebels, Arthur L Beaudet   +9 more
doaj   +1 more source

Late Quaternary climatic variability in the Eastern Mediterranean recorded in Hermes Cave, Corinth Rift, Greece

Journal of Quaternary Science, EarlyView.
ABSTRACT The Greek peninsula lies at the intersection of major atmospheric circulation systems, making it a key location for reconstructing past climate variability in the Eastern Mediterranean. In this study, we present a new high‐resolution multi‐proxy speleothem record from Hermes Cave, located on the shoulder of the Corinth Rift in southern Greece.
Ch. Pennos, S. Pechlivanidou, S. Modestou, A. Persoiu, S.F.M. Breitenbach, U. Ninnemann, R.L. Gawthorpe, J. Maccali, S‐E. Lauritzen, R.Ø. Skoglund, Th. Thuesen   +10 more
wiley   +1 more source

Role of E6-Associated Protein (E6-AP) in Mammary Gland Development and Tumorigenesis

, 2009
E6-associated protein (E6-AP), which was originally identified as an ubiquitin-protein ligase, also functions as a co-activator that enhances the hormone-dependent transactivation of estrogen (ER) and progesterone (PR) receptors.
Ramamoorthy, Sivapriya
core   +1 more source