Results 81 to 90 of about 327,500 (191)

Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome

Neurobiology of Disease, 2015
Genetic defects in the UBE3A gene, which encodes for the imprinted E6-AP ubiquitin E3 ligase (UBE3A), is responsible for the occurrence of Angelman syndrome (AS), a neurodegenerative disorder which arises in 1 out of every 12,000–20,000 births. Classical
Katrina J. Llewellyn, Angèle Nalbandian, Arianna Gomez, Don Wei, Naomi Walker, Virginia E. Kimonis   +5 more
doaj   +1 more source

Proteasome inhibition or knock-down of E6-AP increases the levels of pro-IL-1β in immortalized E6-positive cells.

, 2013
A) ELISA of intracellular IL-1β from untreated immortalized HPV-positive cells and cells incubated with 10 µM of the proteasome inhibitor MG132 for 6 h.
Frank Rösl (147752), Gerd Böhmer (440625), Bladimiro Rincon-Orozco (440626), Andreas M. Kaufmann (231656), Daniela Höfler (440621), Vlada Kogosov (440622), Xu Qian (188503), Martina Niebler (440620), Rainer Zawatzky (277657), Jittranan Kaewprag (440623), Regina Ly (440624)   +10 more
core   +1 more source

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

Journal of Biological Chemistry, 2008
The accumulation of intracellular protein deposits as inclusion bodies is the common pathological hallmark of most age-related neurodegenerative disorders including polyglutamine diseases. Appearance of aggregates of the misfolded mutant disease proteins suggest that cells are unable to efficiently degrade them, and failure of clearance leads to the ...
Amit, Mishra, Priyanka, Dikshit, Sudarshana, Purkayastha, Jaiprakash, Sharma, Nobuyuki, Nukina, Nihar Ranjan, Jana   +5 more
openaire   +2 more sources

Dynamic Trust Formation in AI‐Enabled Automation: A Longitudinal Case Study of an Advanced Driver Assistance System

Information Systems Journal, EarlyView.
ABSTRACT Artificial intelligence (AI)–enabled automation is often utilised in systems that perform human tasks. While useful, these technologies pose a risk of adverse consequences in the case of AI failures as they operate in open environments, learn and are subject to continuous updates.
Kari M. Koskinen, Niina Mallat, Virpi Kristiina Tuunainen, Antti Lyyra   +3 more
wiley   +1 more source

HECT‐Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin‐Interacting Protein and Ameliorates Reactive Oxygen Species–Induced Cardiotoxicity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe homologous to the E6‐AP carboxyl terminus (HECT)–type ubiquitin E3 ligase ITCH is an enzyme that plays a pivotal role in posttranslational modification by ubiquitin proteasomal protein degradation. Thioredoxin‐interacting protein (TXNIP) is
Yoichiro Otaki, Hiroki Takahashi, Tetsu Watanabe, Akira Funayama, Shunsuke Netsu, Yuki Honda, Taro Narumi, Shinpei Kadowaki, Hiromasa Hasegawa, Shintaro Honda, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Hideaki Kamata, Osamu Nakajima, Isao Kubota   +15 more
doaj   +1 more source

A role for amphiphysin in AP-1/clathrin coat formation [PDF]

, 2013
Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. Clathrin, in combination with different adaptor proteins, is the major coat protein for vesicle formation at the plasma membrane, endosomes, and the ...
Huser Studer, Sonja
core   +1 more source

E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box [PDF]

Journal of Biological Chemistry, 1998
Ubiquitin ligases are generally assumed to play a major role in substrate recognition and thus provide specificity to a particular ubiquitin modification system. The multicopy maintenance protein (Mcm) 7 subunit of the replication licensing factor-M was identified as a substrate of the E3-ubiquitin ligase/E6-AP by its interaction with human ...
Christian Kühne, Lawrence Banks
openaire   +3 more sources

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

HPV16 E7 modulates the cell surface expression of MET and CD109 via the AP2 complex

Tumour Virus Research
Multiple cellular pathways are affected by HPV E6 and E7 oncoproteins, including endocytic and cellular trafficking. HPV-16 E7 can target the adaptor protein (AP) complex, which contains proteins important during endocytosis transport.
Oscar Trejo-Cerro, Om Basukala, Michael P. Myers, Lawrence Banks   +3 more
doaj   +1 more source

Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women

, 2014
Silencing of HPV oncogenes or their human host client proteins using topically applied small interfering RNA (siRNA) may be an attractive nonsurgical strategy for CIN treatment.
Hillemanns, P, Hass, R, Jentschke, M, Soergel, P, Evans, TG   +4 more
core