Results 41 to 50 of about 327,500 (191)

Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

Molecular Cancer, 2011
Background- Specific types of high risk Human papillomaviruses (HR-HPVs) particularly, HPV types 16 and 18 cause cervical cancer and while the two recently developed vaccines against these HPV types are prophylactic in nature, therapeutic options for ...
Husain Syed A, Tyagi Abhishek, Shukla Shirish, Bharti Alok C, Mahata Sutapa, Das Bhudev C   +5 more
doaj   +1 more source

Genome-wide analysis of HECT E3 ubiquitin ligase gene family in Solanum lycopersicum

Scientific Reports, 2021
The E3 ubiquitin ligases have been known to intrigue many researchers to date, due to their heterogenicity and substrate mediation for ubiquitin transfer to the protein.
Bhaskar Sharma, Harshita Saxena, Harshita Negi   +2 more
doaj   +1 more source

Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4. [PDF]

PLoS Pathogens, 2016
We investigated the mechanism of how the papillomavirus E2 transcription factor can activate promoters through activator protein (AP)1 binding sites. Using an unbiased approach with an inducible cell line expressing the viral transcription factor E2 and ...
Maria Delcuratolo, Jasmin Fertey, Markus Schneider, Johanna Schuetz, Natalie Leiprecht, Benjamin Hudjetz, Stephan Brodbeck, Silke Corall, Marcel Dreer, Roxana Michaela Schwab, Martin Grimm, Shwu-Yuan Wu, Frank Stubenrauch, Cheng-Ming Chiang, Thomas Iftner   +14 more
doaj   +1 more source

Cardiac-specific ITCH overexpression ameliorates septic cardiomyopathy via inhibition of the NF-κB signaling pathway

Journal of Molecular and Cellular Cardiology Plus, 2022
Background: Septic cardiomyopathy is a common complication of septic shock and organ dysfunction. ITCH is a HECT (homologous to the E6-AP carboxyl-terminus)-type ubiquitin E3 ligase that plays a critical role in inflammatory suppression.
Yuji Saito, Yoichiro Otaki, Tetsu Watanabe, Shingo Tachibana, Junya Sato, Yuta Kobayashi, Tomonori Aono, Jun Goto, Masahiro Wanezaki, Daisuke Kutsuzawa, Shigehiko Kato, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Masafumi Watanabe   +15 more
doaj   +1 more source

Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome

Neurobiology of Disease, 2010
E6 associated protein is an E3 ubiquitin ligase encoded by the gene Ube3a. Deletion or loss of function of the maternally inherited allele of Ube3a leads to Angelman syndrome.
Shalaka A. Mulherkar, Nihar Ranjan Jana
doaj   +1 more source

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives

Molecular Medicine, 2023
The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the selective executers in the protein ubiquitination, playing a vital role in modulation of the protein function and stability. Evidence shows the regulatory role of HECT-
Rui Zhang, Shaoqing Shi
doaj   +1 more source

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia

Emerging Infectious Diseases, 2008
Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%.
Boris Klempa, Evgeniy A. Tkachenko, Tamara K. Dzagurova, Yulia V. Yunicheva, Vyacheslav G. Morozov, Natalia M. Okulova, Galina P. Slyusareva, Aleksey Smirnov, Detlev H. Kruger   +8 more
doaj   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Neurobehavioral and Electroencephalographic Abnormalities in Ube3aMaternal-Deficient Mice

Neurobiology of Disease, 2002
Angelman syndrome (AS), characterized by motor dysfunction, mental retardation, and seizures, is caused by several genetic etiologies involving chromosome 15q11–q13, including mutations of the UBE3A gene.
Kiyonori Miura, Tatsuya Kishino, En Li, Hayley Webber, Pieter Dikkes, Gregory L. Holmes, Joseph Wagstaff   +6 more
doaj   +1 more source

Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome

Neurobiology of Disease, 2010
Angelman syndrome (AS) is a neurogenetic disorder caused by loss of maternal UBE3A expression or mutation-induced dysfunction of its protein product, the E3 ubiquitin–protein ligase, UBE3A.
Richard M. Gustin, Terry Jo Bichell, Michael Bubser, Jennifer Daily, Irina Filonova, Davit Mrelashvili, Ariel Y. Deutch, Roger J. Colbran, Edwin J. Weeber, Kevin F. Haas   +9 more
doaj   +1 more source