Results 31 to 40 of about 327,500 (191)
The ubiquitin ligase E6‐AP promotes degradation of α‐synuclein [PDF]
Journal of Neurochemistry, 2009 AbstractParkinson’s disease (PD) is a common neurodegenerative disorder caused mainly because of the loss of dopaminergic neurons in the substantia nigra. Protein inclusions called Lewy bodies are the most common pathological hallmark of PD and other synucleinopathies.
Shalaka A, Mulherkar +2 more
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The ubiquitin ligase UBE3A dampens ERK pathway signalling in HPV E6 transformed HeLa cells. [PDF]
PLoS ONE, 2015 Signalling through the ERK MAP kinase pathway plays an important role in many biological processes and it is often deregulated in disease states such as cancer.
Elisa Aguilar-Martinez +2 more
doaj +1 more source
Erratum: UBE3A/E6-AP mutations cause Angelman syndrome [PDF]
Nature Genetics, 1997 Nature Genetics 15, 70–73 (1997). In Fig. 2, nucleotide 61 should have been coloured red, indicating it as part of exon 1. Our apologies for any difficulties this may have caused.
T. Kishino, M. Lalande, J. Wagstaff
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Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. [PDF]
PLoS ONE, 2011 Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia.
Jennifer L Daily +9 more
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Subcellular organization of UBE3A in human cerebral cortex
Molecular Autism, 2018 Background Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Alain C. Burette +6 more
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Genomic Organization of theUBE3A/E6-AP Gene and Related Pseudogenes
Genomics, 1998 The UBE3A gene encodes the E6-AP ubiquitin-protein ligase and has recently been shown to be mutated in Angelman syndrome patients who lack 15q11-q13 deletions or chromosome 15 paternal uniparental disomy. Previous UBE3A cDNA analysis has shown a coding region of approximately 2.6 kb and a 3'-untranslated region (UTR) of < 50 bp, whereas Northern ...
T, Kishino, J, Wagstaff
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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. [PDF]
Proceedings of the National Academy of Sciences, 1995 E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. E6-AP is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in ...
J M, Huibregtse +3 more
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Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25. [PDF]
The EMBO Journal, 1996 The level of the mitotic activating tyrosine phosphatase cdc25 is regulated by both transcriptional and post-transcriptional mechanisms in the fission yeast Schizosaccharomyces pombe. We have found that cdc25 is ubiquitinated and have cloned pub1, a gene which regulates this event.
B, Nefsky, D, Beach
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PLoS Pathogens, 2021 Intracellular pathogens have evolved to utilize normal cellular processes to complete their replicative cycles. Pathogens that interface with proliferative cell signaling pathways risk infections that can lead to cancers, but the factors that influence ...
Adrian J Luna +14 more
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Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent
Journal of General Virology, 2004 An important characteristic of the E6 proteins derived from cancer-associated human papillomaviruses (HPVs) is their ability to target cellular proteins for ubiquitin-mediated degradation. Degradation of the p53 tumour suppressor protein by E6 is known to involve the cellular ubiquitin ligase, E6-AP; however, it is presently not known how E6 targets ...
Helena Sterlinko, Grm, Lawrence, Banks
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